2011 Fiscal Year Final Research Report
The development of clinical diagnosis for frontotemporal lobar degeneration
| Project/Area Number |
22791157
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2010) |
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Principal Investigator |
HOSOKAWA Masato 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (00435116)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 前頭側頭葉変性症 / TDP-43 / ELISA / 脳脊髄液 / 筋萎縮性側索硬化症 |
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| Research Abstract |
We established the method for quantification of TAR DNA-binding protein of 43 kDa(TDP-43) that was recently identified in frontotemporal lobar degeneration(FTLD) and amyotrophic lateral sclerosis(ALS). Compared with cerebrospinal fluid of ALS and Guillain-Barre syndrome patients, TDP-43 concentration of ALS patients was significantly higher than Guillain-Barre syndrome patients. These results indicated that this method could be useful in the early diagnosis of FTLD.
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