2011 Fiscal Year Final Research Report
Molecular mechanisms and effects of X-ray and particle beam for invasiveness in glioblastoma cell
| Project/Area Number |
22791166
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
YOSHIDA Yukari 群馬大学, 重粒子線医学推進機構, 助教 (90431717)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 遊走 / 重粒子線 / 悪性脳腫瘍 |
|---|
| Research Abstract |
Human glioblastoma cell lines were irradiated with X-rays or carbon ion beams. Not only X-rays but carbon ion beams increased cell motility at 24 hours after irradiation. Blockage of .-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor suppressed migration in glioblastoma cells. Expression of E-and N-cadherin proteins was changed by irradiation and glutamate receptor antagonist. These results suggest that glutamate and cadherin might play a role in facilitation of glioblastoma cell motility by irradiation. And also, glutamate receptor antagonist may useful inhibitor for cell migration in radiation therapy of glioblastoma.
|
