2011 Fiscal Year Final Research Report
Molecular biological investigation about the effect of heavy-ion beam on normal brain
| Project/Area Number |
22791167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
SUZUKI Yoshiyuki 群馬大学, 大学院・医学系研究科, 准教授 (60334116)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 炭素イオン線 / 悪性脳腫瘍 / 遊走能 / 増感剤 / ニューロン |
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| Research Abstract |
1) Carbon-ion beams were about 10-fold more effective than X-rays in immature hippocampal neurons. X-irradiation immediately induced morphological changes in axons and dendrite. These changes seemed to be caused by x-irradiation evoking depolymerization of microfilament.
2) Under severe hypoxic condition for 1 hour, oxygen enhancement ratio (OER) of X-ray was calculated as 2.7. Also, Under severe hypoxic condition for 24 hour, OER of X-ray was calculated as 2.6. OER was decreased to 1.1 by the combination use of X-ray irradiation and mTOR inhibitor. However, OER was not changed by combination use of carbon-ion beam irradiation and mTOR inhibitor.
3) The RBE of C-beams to X-rays in the normal cerebellum of infant rats with rat organotypic slice culture system was assumed to be 1.4.
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Research Products
(27 results)
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[Journal Article] Expression of hypoxia-inducible factor 1α predicts clinical outcome after preoperative hyperthermo-chemoradiotherapy for locally advanced rectal cancer2011
Author(s)
Shioya M, Takahashi T, Ishikawa H, Sakurai H, Ebara T, Suzuki Y, Saitoh J, Ohno T, Asao T, Hiroyuki K, Nakano T
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Journal Title
J Radiat Res (Tokyo)
Volume: 52(6)
Pages: 821-7
Peer Reviewed
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[Journal Article] Development of head module for multi-head Si/CdTe Compton camera for medical applications2011
Author(s)
Yamaguchi M, Kawachi N, Suzui N, Fujimaki S, Kamiya T, Odaka H, Ishikawa S, Kokubun M, Watanabe S, Takahashi T, Shimada H, Arakawa K, Suzuki Y, Torikai K, Yoshida Y, Nakano T. Nucl
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Journal Title
Instr. Meth. Phys. Res.
Volume: 648
Pages: S2-S7
Peer Reviewed
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[Journal Article] The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Iliac Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer : A Dosimetric Study2010
Author(s)
Oike T, Ohno T, Wakatsuki M, Noda SE, Saitoh JI, Mizukami T, Yoshimoto Y, Okonogi N, Katoh H, Shibuya K, Suzuki Y, Ishikawa H, Ebara T, Takahashi T, Nakano T.
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Journal Title
J Radiat Res (Tokyo)
Volume: 51(6)
Pages: 715-21
Peer Reviewed
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[Journal Article] Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons2010
Author(s)
Kaminuma T, Suzuki Y, Shirai K, Mizui T, Noda SE, Yoshida Y, Funayama T, Takahashi T, Kobayashi Y, Shirao T, Nakano T
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Journal Title
J Radiat Res (Tokyo)
Volume: 51(6)
Pages: 627-31
Peer Reviewed
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[Journal Article] Higher pAkt expression predicts a significant worse prognosis in glioblastomas2010
Author(s)
Suzuki Y, Shirai K, Oka K, Mobaraki A, Yoshida Y, Noda SE, Okamoto M, Suzuki Y, Itoh J, Itoh H, Ishiuchi S, Nakano T.
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Journal Title
J Radiat Res (Tokyo)
Volume: 51(3)
Pages: 343-8
Peer Reviewed
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[Presentation] X ray Irradiation Induces Acute Depolymerization of Axonal and Dendritic Microfilaments in Cultured Neuron2011
Author(s)
Suzuki Y, Hino M, Shirai K, Yoshida Y, Mizui T, Hanamura K, Shirao T, Nakano T
Organizer
American Society for Radiation Oncology 53th annual meeting
Place of Presentation
Miami Beach Convention Center, Miami Beach, FL, USA
Year and Date
20111002-06
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