2011 Fiscal Year Final Research Report
Fundamental research of X-ray and carbon ion beam radiation sensitivity for the treatment of hypoxic tumor cells and investigation of its molecular biological mechanism.
| Project/Area Number |
22791171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
SAITOH Jun-ichi 群馬大学, 大学院・医学系研究科, 講師 (70572816)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 放射線感受性 / 低酸素 / HIF-1α / 一酸化窒素 |
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| Research Abstract |
Changes of the expression of hypoxic marker HIF-1αand radiation sensitivity under hypoxic conditions with HIF-1αinhibitor were investigated. Hypoxic tumor cells were exposed to radiation with or without HIF-1αinhibitor YC-1 or nitric oxide synthase inhibitor L-NMMA. The expressions of HIF-1αunder hypoxic conditions (>0.1mmHg) were inhibited with YC-1 or L-NMMA, but radiosensitizing effects with these drugs under acute hypoxic conditions were not observed.
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