2011 Fiscal Year Final Research Report
Acceleration of Cerebral Blood Flow and Oxygen Metabolism Measurement with Injectable 15O labeled Radiotracers and Effectiveness of Drug Treatment
| Project/Area Number |
22791180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 核医学(PET) / 核医学(PET) / 脳循環代謝 |
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| Research Abstract |
We developed cerebral blood flow and oxygen metabolism measurement combining injectable 15O labeled artificial blood cell and noninvasive rapid steady-state method. The cerebral blood flow and oxygen metabolism of normal and cerebral ischemia-reperfusion model rat was measured and then effectiveness of drug treatment was evaluated using this method. New rapid steady-state method was developed by combining membrane plasma separator to conventional steady-state method and cerebral blood flow and oxygen metabolism of normal and cerebral occlusion region was calculated easily, rapidly and accurately. Influence of isoflurane gas anaesthesia was confirmed using the method.
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