2011 Fiscal Year Final Research Report
Metabolic imaging using fluorinated hexoses in tumor bearing mouse by 19F MRS/MRI
| Project/Area Number |
22791186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
NARAZAKI Michiko 京都大学, 大学院・情報学研究科, 特定研究員 (10467459)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 核磁気共鳴画像(MRI) / 多核種 / 19F |
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| Research Abstract |
19F MRS/MRI using 2-deoxy-2-fluoro-D-glucose(FDG) was explored as a method for quantitative imaging towards characteristic diagnosis of tumor. 19FDG metabolic images were obtained at the tumor position at 0. 5, 3, 24, 48 hour after FDG injection. Metabolites were quantified in tumor tissue and organs excised after the imaging, and the detailed analysis was performed as water extracts by 19F NMR. In the excised tissue, FDG metabolites were retained for a long time at the high concentration. 19F MRS/MRI was shown to be an excellent method for tumor characterization reflecting metabolic specificity.
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[Journal Article] Constitutive SIRT1 Overexpression Impairs Mitochondia and Reduces Cardiac Function in Mice2011
Author(s)
T kawashima, Y Inuzuka, J Okuda, T Kato, S Niizuma, Y Tamaki, Y Iwanaga, A Kawamoto, M Narazaki, T Matsuda, S Adachi, G Takemura, T Kita, T Kimura, T Shioi
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 51
Pages: 511026-1036
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