2011 Fiscal Year Final Research Report
Development of MMP dependent anchoring probe for diagnosis of tumor malignancy
| Project/Area Number |
22791189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
TEMMA Takashi 京都大学, 大学院・薬学研究科, 助教 (90378787)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 放射性医薬品 / 造影剤 |
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| Research Abstract |
This study aimed to develop a MT1-MMP dependent anchoring probe(MDAP) which is composed of MMP substrate peptide, RI signal domain, cell membrane anchoring domain and inhibitable domain. A MT1-MMP substrate peptide useful for in vivo imaging was obtained and 111In-MDAP was successfully synthesized using a MMP2 substrate peptide as a model. In vitro study with MMP high and low expressed cells and in vivo study with normal mice revealed that 111In-MDAP could be a promising imaging agent in vivo.
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