2011 Fiscal Year Final Research Report
Study of improvement depiction of carcinoma in Lactsome fluorescence/PET imaging
| Project/Area Number |
22791192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 核医学 / 分子イメージング / ナノキャリア / ミセル / SPECT / PET / EPR効果 / 腫瘍イメージング / 転移モデル |
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| Research Abstract |
We aimed at a development of the nanocarrier who is able to diagnose carcinoma. By using the Lactsome labeled by ICG, or 18F, or 123I, this study was performed to improve depiction of carcinoma. We searched the methods how to avoid an Accelerated Blood Clearance(ABC) phenomenon, which peculiarly appeared when the 20-100nm nanocarrier was administered at the second time. As a result, we were able to compose Lactsome labeled by ICG, or 18F, or 123I etc. And we comfirmed small animal PET imaging condition, and performed biodistribution. Besides, we found out some methods to let an ABC phenomenon diminish. However, we were not able to let an ABC phenomenon completely disappear.
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