Optimization of loading superabsorbent polymer microspheres with anticancer drugs for use in chemoembolization of liver tumors unresponsive to standard therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791195
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: MAEDA Noboru 大阪大学, 医学(系)研究科(研究院), 助教 (00506488)
• Project Period (FY): 2010 – 2012
• Keywords: 動脈塞栓術 / 化学塞栓療法 / 薬剤溶出性塞栓物質 / 高吸水性ポリマー / 肝腫瘍 / 抗癌剤 / エピルビシン / イリノテカン

Research Abstract

The purpose of this study was to optimize the preparation for loading superabsorbent polymer (SAP) microspheres with anticancer drugs as an efficient drug delivery system for use in chemoembolization of liver tumors unresponsive to standard therapy in clinical practice. Iodinated contrast medium, nonionic isosmotic iodinated contrast medium and undiluted irinotecan solutions for intravenous drip infusion were most suitable for solvent in loading SAP microspheres with cisplatin, epirubicin and irinotecan, respectively. This result of in vivo study in a rabbit model with transplanted liver VX2 tumors suggested that chemoembolization with anticancer drug-loaded SAP microspheres was more effective in suppressing the tumor growth.

Research Products

• [Journal Article] In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors (2012)
  • Author(s): Maeda N, Osuga K, Shimazu K, Morii E, Mikami K, Hori S, Nakazawa T, Higashihara H, Tomoda K, Nakamura H, Tomiyama N
  • Journal Title: J Vasc Interv Radiol Volume: 23(3):397-404
  • Peer Reviewed
• [Journal Article] In vitro characterization of cisplatin-loaded superabsorbent polymer microspheres designed for chemoembolization (2010)
  • Author(s): Maeda N, Osuga K, Mikami K, Higashihara H, Mikami K, Tomoda K, Hori S, Nakazawa T, Nakamura H
  • Journal Title: J Vasc Interv Radiol Volume: 21(6):877-81
  • Peer Reviewed
• [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討 (2013)
  • Author(s): 岸本健太郎、前田登、日高国幸、大須賀慶悟、田中会秀、中村純寿、小野祐介、中澤哲郎、東原大樹、富山憲幸
  • Organizer: 第42回日本IVR学会総会
  • Place of Presentation: 軽井沢
  • Year and Date: 2013-05-16
• [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討 (2013)
  • Author(s): 岸本健太郎、前田登、大須賀慶悟、田中会秀、中村純寿、小野祐介、中澤哲郎、東原大樹、富山憲幸
  • Organizer: 第72回日本医学放射線学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-04-14
• [Presentation] In vitro characterization of epirubicin-loaded Hepaspheres (superabsorbent polymer microspheres) designed for chemoembolization (2012)
  • Author(s): Maeda N, Osuga K, Tanaka K, Kishimoto K, Nakamura M, Nakazawa T, Higashihara H, Tomoda K, Tomiyama N.
  • Organizer: American Roentgen Ray Society (ARRS) 2012 Annual Meeting
  • Place of Presentation: Vancouver,Canada
  • Year and Date: 2012-04-29
• [Presentation] エピルビシンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討 (2011)
  • Author(s): 前田登、大須賀慶悟、東原大樹、中澤哲郎、友田要、富山憲幸
  • Organizer: 第70回日本医学放射線学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20110500
• [Presentation] エピルビシンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討 (2011)
  • Author(s): 前田登、大須賀慶悟、東原大樹、中澤哲郎、友田要、富山憲幸
  • Organizer: 第40回日本IVR学会総会
  • Place of Presentation: 青森
  • Year and Date: 2011-05-20