Development of oral contrast agent for esophageal CT

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TSURUMARU Daisuke 九州大学, 大学病院, 医員 (90419565)
• Project Period (FY): 2010 – 2011
• Keywords: 食道癌 / CT

Research Abstract

We prepared pig esophagus for this experiment. Tumors were endoscopically made in the esophagus by injecting a certain amount of hyaluronate sodium. Contrast agents were composed of 2, 5, and 10% of standard barium sulfate solution with thickening agent. After filling the pig esophagus with the agents, CT scans were performed. Transverse and longitudinal images were reviewed. As a result, contrast agents composed of 5 or 10% solution were optimal condition. Oral contrast agent may be possible of clinical use in CT evaluation of esophageal cancers.

Research Products

• [Journal Article] Unusual presentation of an esophageal foreign body granuloma caused by a fish bone: usefulness of multidetector computed tomography (2011)
  • Author(s): Kikuchi K, Tsurumaru D, Hiraka K, Komori M, Fujita N, Honda H.
  • Journal Title: Jpn J Radiol Volume: 29(1) Pages: 63-6
• [Journal Article] Esophageal Stenosis Associated with Tumor Regression in Radiotherapy for Esophageal Cancer : Frequency and Prediction (2011)
  • Author(s): Atsumi K, Shioyama Y, Arimura H, Terashima K, Matsuki T, Ohga S, Yoshitake T, Nonoshita T, Tsurumaru D, Ohnishi K, Asai K, Matsumoto K, Nakamura K, Honda H.
  • Journal Title: Int J Radiat Oncol Biol Phys Pages: 6
• [Journal Article] 1. Gastric mucosal changes caused by Lugol' s iodine solution spray (2010)
  • Author(s): Tsurumaru D, Utsunomiya T, Matsuura S, Komori M, Kawanami S, Ishibashi T, Honda H. Gastroenterol Res Pract
  • Journal Title: endoscopic features of 64 cases Pages: 494195
• [Presentation] 食道癌術前化学放射線療法(NACRT)の効果判定における食道造影X線検査の有用性 (2011)
  • Author(s): 鶴丸大介、平賀聖久、古森正宏、川波哲、塩山善之、本田浩
  • Organizer: 第70回日本医学放射線学会総会
  • Year and Date: 20110509-20
• [Presentation] 食道癌のCT診断向上を目的とした経口造影剤の可能性について:ブタ食道を用いた実験結果から (2011)
  • Author(s): 鶴丸大介、古森正宏、内田耕栄、浅山良樹、本田浩
  • Organizer: 第71回日本医学放射線学会総会
  • Year and Date: 20110412-15
• [Presentation] 1. Clinical Role of Double-Contrast Barium Esophagography in Patients with Esophageal Cancer (2011)
  • Author(s): D. Tsurumaru, K. Hiraka, M. Komori, S. Kawanami, Y. Shioyama, H. Honda
  • Organizer: Determination of Therapeutic Strategy in the Course of Neoadjuvant Chemoradiotherapy
  • Place of Presentation: European Radiology Congress
  • Year and Date: 20110303-07