2011 Fiscal Year Final Research Report
Molecular-targeted therapy of venous thromboembolism
| Project/Area Number |
22791206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 深部静脈血栓症 / 遺伝子導入 / 静脈 / Clec-2 |
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| Research Abstract |
Platelet activation receptor CLEC-2 binds to podoplanin, thereby leading to platelet activation and thrombus formation. The present study examines whether local gene transfer suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to venous wall competitively. As a result, although further studies are needed, the possibility of persistent expression of target protein and antithrombotic effect were suggested in a rat model of venous thrombosis.
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