2011 Fiscal Year Final Research Report
Hyaluronan-Conjugated nanoparticles as carrier of sodium borocaptate for tumor targeting in boron neutron capture therapy
| Project/Area Number |
22791229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | BNCT / メラノーマ / DDS / ヒアルロン酸 |
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| Research Abstract |
We have developed a strategy for targeting sodium borocaptate in melanoma boron neutron capture therapy. The boron-retention capacity of boron formulations was very high. All boborocaptate-loaded nanoparticles had no cytotoxic effects. Hyaluronan-Conjugated nanoparticles readily bound to melanoma cells, and were internalized by receptor-mediated endocytosis. Thermal neutron irradiation yielded tumor growth suppression on B16F10 murine melanoma and COLO679 human melanoma with the Hyaluronan-Conjugated nanoparticles.
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