Myelin mapping using q-space imaging

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791230
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: 実験動物中央研究所 (2011); Central Institute for Experimental Animals (2010)
• Principal Investigator: HIKISHIMA Keigo 実験動物中央研究所, 病理病態研究部, 研究員 (30420219)
• Project Period (FY): 2010 – 2011
• Keywords: 磁気共鳴画像(MRI)

Research Abstract

We focused a unique water diffusivity restricted by myelin structure and developed its imaging method using magnetic resonance imaging(MRI). Because of the non-invasiveness and myelin specificity, this method could be a powerful diagnosis tool for the investigation of the process of neurological and psychological diseases, with which the myelin disruption is potentially associated.

Research Products

• [Journal Article] Population-averaged standard template brain atlas for the common marmoset (2011)
  • Author(s): Hikishima K, Quallo MM, Komaki Y, Yamada M, Kawai K, Momoshima M, Okano HJ, Sasaki E, Tamaoki N, Lemon RN, Iriki A, Okano H.
  • Journal Title: Neuro Image Volume: 54 Pages: 2741-9
  • DOI: doi:10.1016/j.neuroimage.
  • Peer Reviewed
• [Journal Article] 脊髄損傷モデルの拡散MRI (2010)
  • Author(s): 疋島啓吾、藤吉兼浩、岡野栄之
  • Journal Title: Medical Science Digest Volume: vol36, no.11 Pages: 1038-41
• [Presentation] QSIのシーケンス実装と撮影の実際 (2011)
  • Author(s): 疋島啓吾, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州
  • Year and Date: 2011-09-30
• [Presentation] q-space imaging (2010)
  • Author(s): 疋島啓吾
  • Organizer: 第43回Radiology Update学術講演会
  • Place of Presentation: 品川
  • Year and Date: 2010-10-30
• [Presentation] Diffusion microscopic tractograpgy using CryoProbe (2010)
  • Author(s): 疋島啓吾
  • Organizer: 第二回q-space imaging研究会
  • Place of Presentation: つくば
  • Year and Date: 2010-09-30
• [Presentation] 拡散MRIによる脊髄損傷の解析 (2010)
  • Author(s): 疋島啓吾, 他
  • Organizer: 第14回NMRマイクロイメージング研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-06
• [Presentation] Myelin visualization using q-space MRI (2010)
  • Author(s): Hikishima, K., et al
  • Organizer: International Society for Magnetic Resonance in Medicine(ISMRM) 18^<th> annual meeting
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-05-01
• [Presentation] Resolving of Crossing Pathways in the Optic Chiasm of Marmoset Monkey using Diffusion Tractography with High Spatial and Angular Resolution (2010)
  • Author(s): Hikishima, K., et al
  • Organizer: International Society for Magnetic Resonance in Medicine(ISMRM) 18^<th> annual meeting
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-05-01