Standardization of patient dosimetry and investigation of the efficacy of radioprotective agent during neuroendovascular procedure

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: 公益財団法人冲中記念成人病研究所 (2012); Okinaka Memorial Institute for Medical Research (2010-2011)
• Principal Investigator: HAYAKAWA Mikito 公益財団法人冲中記念成人病研究所, 研究員 (80450229)
• Project Period (FY): 2010 – 2012
• Keywords: 蛍光ガラス線量計 / 皮膚透過線量 / インターベンショナル・ラジオロジー / 医療被ばく / 脳血管内治療

Research Abstract

We established a direct dosimetry method of patients’ entrance skin doses during neuroendovascular procedure using multiple radiophotoluminescence glass dosimeters. We applied this dosimetry system in clinical neuroendovascular settings, and clarified the frequency of maximum entrance skin dose (ESD) over 3 Gy, the prevalence of temporary epilation as a radiation-induced skin injury, and the difference of radiation-dose distributions between single-plane and bi-plane angiography equipments. In addition, we clarified that total fluoroscopic time and dose-area products were clearly related to maximum ESD and we could estimate the ESD in real-time during neuroendovascular procedure. These results could be the fundamental data to reduce radiation exposure during neuroendovascular procedure and to apply the radioprotective agent in a clinical setting in the near future.

Research Products

• [Journal Article] Precise mapping system of entrance skin dose during endovascular embolization for cerebral aneurysm (2011)
  • Author(s): Moritake T, Hayakawa M, Matsumaru Y, Takigawa T, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, Tsuboi K, Sakae T, Sakurai H.
  • Journal Title: Radiation Measurements Volume: 46 Pages: 2103-2106
• [Journal Article] Direct measurement of patient's entrance skin dose during neurointerventional procedure to avoid further radiation-induced skin injuries (2010)
  • Author(s): Hayakawa M, Moritake T, Kataoka F, Takigawa T, Koguchi Y, Miyamoto Y, Akahane K, Matsumaru Y.
  • Journal Title: Clin Neurol Neurosurg Volume: 112 Pages: 530-536
• [Presentation] 脳血管内治療における被ばく線量分布の検討―シングルプレーン・バイプレーン装置間比較― (2012)
  • Author(s): 早川幹人、盛武敬、松丸祐司、川内覚、小口靖弘、宮本由香、赤羽恵一、榮武二、坪井康次、櫻井英幸
  • Organizer: 第28回日本脳神経血管内治療学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20121115-17
• [Presentation] Difference of skin dose distribution between bi-plane and single-plane systems during neurointerventional procedures (2012)
  • Author(s): Hayakawa M, Moritake T, Matsumaru Y, Kawauchi S, Koguchi Y, Miyamoto Y, Akahane K, Sakae T, Tsuboi K, Sakurai H
  • Organizer: 2012 World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing, China
  • Year and Date: 20120526-31
• [Presentation] X-ray shielding device for reduction of the irradiation dose to the lens during neurointerventional procedures (2012)
  • Author(s): Moritake T, Koizumi H, Matsumaru Y, Hayakawa M, Akahane K, Isobe T, Sakae T, Sakurai H, Tsuboi K
  • Organizer: 2012 World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing, China
  • Year and Date: 20120526-31
• [Presentation] 眼球水晶体遮蔽装置の開発と効果の検証 (2011)
  • Author(s): 大山高一、盛武敬、松丸祐司、小泉洋人、磯辺智範、高橋英希、赤羽恵一、早川幹人、宮本俊男、鶴岡伊知郎、渡邊和洋、坪井康次
  • Organizer: 第27回日本脳神経血管内治療学会総会
  • Place of Presentation: 幕張
  • Year and Date: 20111124-26
• [Presentation] Precise mapping of entrance skin dose during neurointerventional procedure: what is the most effective method to avoid radiation-induced skin injury? (2010)
  • Author(s): Moritake T, Hayakawa M, Matsumaru Y, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, Tsuboi K, Sakae T, Sakurai H.
  • Organizer: The 56th Annual Meeting of Radiation Research Society in USA
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 20100926-29
• [Presentation] 脳血管IVRにおける水晶体被ばく低減システムの開発とその効果の検証 (2010)
  • Author(s): 高橋英希、磯辺智範、盛武敬、大山高一、小泉洋人、赤羽恵一、早川幹人、松丸祐司、榮武二
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 20100923-25
• [Presentation] Precise mapping of entrance skin dose during endovascular embolization for cerebral aneurysm to avoid radiation-induced skin injury (2010)
  • Author(s): Moritake T, Hayakawa M, Matsumaru Y, Takigawa T, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, Tsuboi K, Sakae T, Sakurai H.
  • Organizer: 16th International Conference on Solid State Dosimetry
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20100919-24