2011 Fiscal Year Final Research Report
Development of a radioprobe for quantifying brain antioxidant
| Project/Area Number |
22791234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KIKUCHI Tatsuya 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (90392224)
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| Project Period (FY) |
2010 – 2011
|
| Keywords | 分子イメージング / PET / 放射性医薬品 / 酸化ストレス / グルタチオン |
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| Research Abstract |
In this study, we developed radioprobes for quantifying brain glutathione S-transferase(GST), an antioxidant. Several halogenopurine derivatives were evaluated in vitro and in vivo. Among the derivatives, 6-[F^^<18>] fluoro-9-methylpurine and 6-[B^^<76> r] bromo-9-ethylpurine showed favorable properties for quantifying brain GST activity.
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