2011 Fiscal Year Final Research Report
Molecular mechanism of intercellular adhesion molecule-1 in the development of abdominal aortic aneurysms
| Project/Area Number |
22791252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
UCHIDA Haruhito 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00550857)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 血管外科学 / 大動脈瘤 |
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| Research Abstract |
Angiotensin II was infused into apoE deficient mice(SKO) and ICAM-1xapoE double deficient mice(DKO) to develop abdominal aortic aneurysm(AAA). ICAM-1 deficiency in whole body attenuated the development of AAA. Bone marrow transplantation revealed that ICAM-1 deficiency in the recipient mice reduced the development of AAA. This result suggests that ICAM-1 may play an important role in the development of AAA formation in this model.
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