2011 Fiscal Year Final Research Report
Investigation to determine a mechanism for T cell regulatory effects induced by treatment with high-dose immunoglobulin injection after organ transplantation.
| Project/Area Number |
22791253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANAKA Yuka 広島大学, 大学院・医歯薬学総合研究科, 助教 (90432666)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫グロブリン / 免疫寛容 / 臓器移植 |
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| Research Abstract |
In the present study, we aimed to determine a mechanism of T cell regulatory effects induced by treatment with high-dose immunoglobulin injection after organ transplantation. By use of human lymphocyte reaction assay, we have proven that the Fc-part in IgG is responsible for the inhibiting effects on alloreactive T cells. We found that Peptide 289 inhibited proliferation of alloreactive T cells. However, its inhibitory extent was not comparable to conventional immunosuppressants. In addition, we developed a novel method to analyze STAT-signaling in alloreactive T cells in vitro.
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