The Clinical Significance and New Development of Coregulatory Molecules in The Immune Surveillance system of Gastrointestinal Cancers

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791256
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kagoshima University
• Principal Investigator: ARIGAMI Takaaki 鹿児島大学, 医学部歯学部附属病院, 医員 (40527058)
• Co-Investigator(Kenkyū-buntansha): NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577) ; ISHIGAMI Sumiya 鹿児島大学, 医歯学総合研究科, 講師 (90325803) ; UENOSONO Yoshikazu 鹿児島大学, 医歯学総合研究科, 特任准教授 (60398279)
• Project Period (FY): 2010 – 2012
• Keywords: 癌免疫機構 / T 細胞性免疫応答 / 免疫補助刺激分子 / B7 ligand family

Research Abstract

We demonstrated that B7-H3 and B7-H4 were expressed in circulating and primary gastric tumor cells. These expressions were related to tumor aggressiveness, including prognosis, in patients with gastric cancer. The evaluation of these expressions could be useful as a tool for predicting tumor aggressiveness. Further understanding of B7-H3/B7-H4 immunological role might allow the development of a new targeted immunotherapy that inhibits these signaling pathways in patients with gastric cancer.

Research Products

• [Journal Article] linical Significance of Lymph Node Micrometastasis in Gastric Cancer (2013)
  • Author(s): Arigami T, Uenosono Y, Yanagita S, Nakajo A, Ishigami S, Okumura H, Kijima Y, Ueno S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 20 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Expression of Stanniocalcin 1 as a Potential Biomarker of Gastric Cancer (2012)
  • Author(s): Arigami T, Uenosono Y, Ishigami S, Hagihara T, Haraguchi N, Matsushita D, Yanagita S, Nakajo A, Okumura H, Hokita S, Natsugoe S
  • Journal Title: Oncology Volume: 83 Pages: 158-164
  • Peer Reviewed
• [Journal Article] 胃癌におけるリンパ行性微小転移の臨床的意義と新たな臨床応用への展開 (2012)
  • Author(s): 有上貴明, 上之園芳一, 柳田茂寛, 萩原貴彦, 原口尚士, 松下大輔, 有馬豪男,平田宗嗣, 中条哲浩, 石神純也, 夏越祥次
  • Journal Title: リンパ学 Volume: 35(1) Pages: 38-42
  • Peer Reviewed
• [Journal Article] 胃癌センチネルリンパ節生検における術中リンパ節微小転移診断 (2012)
  • Author(s): 有上貴明, 上之園芳一, 柳田茂寛, 萩原貴彦, 原口尚士, 松下大輔, 有馬豪男,平田宗嗣, 石神純也, 夏越祥次
  • Journal Title: 日本外科系連合学会誌 Volume: 37(4) Pages: 737-741
  • Peer Reviewed
• [Journal Article] B7-H3 expression in gastric cancer: A novel molecular blood marker for detecting circulating tumor cells (2011)
  • Author(s): Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S
  • Journal Title: Cancer Sci Volume: 102 Pages: 1019-1024
  • Peer Reviewed
• [Journal Article] Clinical significance of the b7-h4 coregulatory molecule as a novel prognostic marker in gastric cancer (2011)
  • Author(s): Arigami T, Uenosono Y, Ishigami S, Hagihara T, Haraguchi N, Natsugoe S
  • Journal Title: World J Surg Volume: 35 Pages: 2051-2057
  • Peer Reviewed
• [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis (2010)
  • Author(s): Arigami T, Uenosono Y, Hirata M, Hagihara T, Yanagita S, Ishigami S, Natsugoe S
  • Journal Title: J Surg Oncol Volume: 102 Pages: 748-52
  • Peer Reviewed
• [Presentation] 胃癌における新規バイオマーカーB7-H3 および B7-H4 発現の臨床的意義と個別化治療への展開 (2013)
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 柳田茂寛, 萩原貴彦, 原口尚士, 松下大輔,平原徹志, 夏越祥次
  • Organizer: 第85回日本胃癌学会総会
  • Place of Presentation: 大阪府
  • Year and Date: 2013-02-28
• [Presentation] 胃癌における新規バイオマーカーB7-H4 発現の臨床的意義と新たな免疫療法への展開 (2012)
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 萩原貴彦, 原口尚士, 松下大輔, 柳田茂寛, 夏越祥次
  • Organizer: 第44回胃病態機能研究会 (Young World Symposium)
  • Place of Presentation: 熊本市
  • Year and Date: 2012-08-04
• [Presentation] Clinical Significance of Stanniocalcin 1 as a Potential Biomarker of Gastric Cancer (2012)
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 萩原貴彦, 原口尚士, 松下大輔, 柳田茂寛,夏越祥次
  • Organizer: Clinical Significance of Stanniocalcin 1 as a Potential Biomarker of Gastric Cancer
  • Place of Presentation: 広島市
  • Year and Date: 2012-07-12
• [Presentation] Clinical Significance of the B7-H4 Coregulatory Molecule as a Novel Prognostic Marker in Gastric Cancer (2012)
  • Author(s): Takaaki Arigami, Yoshikazu Uenosono, Sumiya Ishigami, Takahiko Hagihara, Naoto Haraguchi, Daisuke Matsushita, Shoji Natsugoe
  • Organizer: 10 th International Conferenceof The Asian Clinical Oncology Society (ACOS)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-06-15
• [Presentation] 胃癌における新規バイオマーカーB7-H4 発現の臨床的意義と個別化治療への展開 (2012)
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 萩原貴彦, 原口尚士, 松下大輔, 奥村浩, 内門泰斗, 喜多芳昭, 夏越祥次
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉市
  • Year and Date: 2012-04-13
• [Presentation] 胃癌における B7-H4 発現の血中遊離癌細胞検出マーカーとしての有用性と臨床的意義について (2011)
  • Author(s): 有上貴明, 上之園芳一, 萩原貴彦, 原口尚士, 石神純也, 夏越祥次
  • Organizer: 第9回日本消化器外科学会大会(JDDW 2011)
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-22
• [Presentation] Expression of stanniocalcin-2 in blood of patients with gastric cancer predicts tumor progression and prognosis (2011)
  • Author(s): Takaaki Arigami, Yoshikazu Uenosono, Sumiya Ishigami, Takahiko Hagihara, Naoto Haraguchi, Shoji Natsugoe
  • Organizer: 8thInternational Symposium on Minimal Residual Cancer
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2011-09-22
• [Presentation] B7-H3 Expression in Gastric Cancer: A Novel Molecular Blood Marker for Detecting Circulating Tumor Cells (2011)
  • Author(s): Takaaki Arigami, Yoshikazu Uenosono, Sumiya Ishigami, Shoji Natsugoe
  • Organizer: The International Surgical Week (ISW) 2011
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-08-30
• [Presentation] 胃癌における新規バイオマーカーを用いた腹水中腫瘍細胞検出の試みと臨床応用 (2011)
  • Author(s): 有上貴明, 上之園芳一, 萩原貴彦, 原口尚士, 石神純也, 夏越祥次
  • Organizer: 第66回日本消化器外科学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-07-15
• [Presentation] 胃癌センチネルリンパ節生検における微小転移診断とその臨床的意義 (2011)
  • Author(s): 有上貴明, 上之園芳一, 柳田茂寛, 萩原貴彦, 原口尚士, 平田宗嗣, 有馬豪男,石神純也, 夏越祥次
  • Organizer: 第36回日本外科系連合学会学術集会(パネルディスカッション)
  • Place of Presentation: 東京都
  • Year and Date: 2011-06-17
• [Presentation] 胃癌におけるリンパ行性微小転移の臨床的意義 (2011)
  • Author(s): 有上貴明, 上之園芳一, 柳田茂寛, 萩原貴彦, 原口尚士, 石神純也, 夏越祥次
  • Organizer: 第35回日本リンパ学会総会(シンポジウム)
  • Place of Presentation: 東京都
  • Year and Date: 2011-06-04
• [Presentation] (2011)
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 萩原貴彦, 原口尚士, 松本正隆, 北薗正樹,内門泰斗, 喜多芳昭, 夏越祥次
  • Organizer: 第111回日本外科学会定期学術集会(誌上開催)
  • Place of Presentation: 東京都
  • Year and Date: 2011-05-26
• [Presentation] B7-H3 Expression in Gastric Cancer: A Novel Molecular Blood Marker for Detecting Circulating Tumor Cells (2010)
  • Author(s): Arigami T, Uenosono Y, Ishigami S, Natsugoe S
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪府
  • Year and Date: 2010-09-24
• [Presentation] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis (2010)
  • Author(s): Arigami T, Uenosono Y, Hirata M, Hagiwara T, Yanagita S, Ishigami S, Natsugoe S
  • Organizer: 9 th International Conference of The Asian Clinical Oncology Society (ACOS)
  • Place of Presentation: Gifu, Japan
  • Year and Date: 2010-08-25
• [Presentation] 胃癌における新規バイオマーカーを用いた末梢循環腫瘍細胞検出の試み (2010)
  • Author(s): 有上貴明, 上之園芳一, 平田宗嗣, 萩原貴彦, 石神純也, 夏越祥次
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関市
  • Year and Date: 2010-07-16
• [Presentation] 胃癌における B7-H3 発現の血中遊離癌細胞検出マーカーとしての有用性と臨床的意義 (2010)
  • Author(s): 有上貴明, 上之園芳一, 平田宗嗣, 萩原貴彦, 柳田茂寛, 石神純也, 夏越祥次
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-10
• [Presentation] 胃癌における B7-H4 発現の臨床的意義について (2010)
  • Author(s): 有上貴明, 上之園芳一, 平田宗嗣, 萩原貴彦, 柳田茂寛, 石神純也, 夏越祥次
  • Organizer: 第82回日本胃癌学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-03-04
• [Book] 外科治療
  • Author(s): 有上貴明, 上之園芳一, 石神純也, 夏越祥次
• [Book] Recent Advances and Research Updates
  • Author(s): Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Akihiro Nakajo, Sumiya Ishigami, Shoji Natsugoe
• [Book] 臨床外科
  • Author(s): 有上貴明, 上之園芳一, 柳田茂寛, 有馬豪男, 平田宗嗣, 萩原貴彦, 原口尚士,舩迫和, 松本正隆, 喜島祐子, 石神純也, 夏越祥次
• [Remarks] ホームページ
  • URL: http://www.rdc.kagoshima-u.ac.jp/rdc/search/upload/natugoe-Med.pdf