2012 Fiscal Year Final Research Report
Novel cancer therapy using Bisabolol and modified Bisabolol
Project/Area Number |
22791273
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
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Research Institution | Nagoya University |
Principal Investigator |
ITATSU Keita 名古屋大学, 医学系研究科, 寄附講座助教 (90534842)
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Project Period (FY) |
2010 – 2012
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Keywords | ビサボロール / 胆管癌 / PI3K-AKT シグナル |
Research Abstract |
We investigated whether Bisabolol has antitumor effects against these cancers. Bisabolol induced a decrease in cell proliferation and viability in cholangiocarcinoma and pancreatic cancer cell lines, but not in pancreatic epithelial cells. Profiling revealed that treatment induced apoptosis and suppressed Akt activation in cholangiocarcinoma. Bisabolol treatment induced the overexpression of early growth response-1 (EGR1). Furthermore, Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of Bisabolol, once a week for three weeks. The results indicate thatBisabolol could be a novel therapeutic option for the treatment of cholangiocarcinoma and pancreatic cancer.
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[Presentation] 膵癌に対するα-ビサボロールの有効性の検討2013
Author(s)
宇野雅紀,國料俊男,横山幸浩,関 崇,江畑智希,角田伸行,伊神 剛,菅原 元,深谷昌秀,板津慶太,上原圭介,吉岡裕一郎,梛野正人
Organizer
平成24年度「個体レベルでのがん研究支援活動」ワークショップ
Place of Presentation
琵琶湖ホテル,大津
Year and Date
2013-02-07