Development of novel adoptive cell therapy using antigen receptor engineering T cells for chemo/radiotherapy-resistant esophageal cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791274
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: IMAI Naoko 三重大学, 大学院・医学系研究科, 助教 (30550975)
• Project Period (FY): 2010 – 2011
• Keywords: がん免疫療法 / T細胞輸注療法 / 抗原受容体改変T細胞 / マルチファンクション性T細胞

Research Abstract

We performed analysis of samples from the clinical trail patients administrated TCR(T cell receptor)-gene transduced lymphocytes and researched on adoptive cell therapy of tumor-specific lymphocytes using mouse model. In the clinical trail patients, TCR-transduced lymphocytes were detected in their peripheral blood as approximately 1% of PBMC. The infused cells have been in vivo persisted in all patients as long as 10 months. In the adoptive cell therapy model of TCR transgenic mouse, presence of CD4+ T cells or integrin signals is elevated CD8+ T cell multifunctionality, and enhanced anti-tumor effect. Furthermore, we have almost established mouse model of the adoptive transfer of TCR-gene transduced lymphocytes.

Research Products

• [Journal Article] T-cellreceptor gene therapy targetingmelanoma-associated antigen-A4 inhibits human tumor growth in non-obesediabetic/SCID/γcnull mice (2012)
  • Author(s): Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, MinenoJ, Takesako K, Ikeda H, and Shiku H
  • Journal Title: Cancer Sci Volume: vol.103 Pages: 17-25
  • Peer Reviewed
• [Presentation] T細胞のマルチファンクション性はその生存性と輸注療法の効果を規定する (2011)
  • Author(s): 今井奈緒子、池田裕明、細井勇人、俵功、山根真妃子、王立楠、森和子、日向千咲、珠玖洋
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] インテグリンシグナルを介した教育による効果的なT細胞療法の確立 (2011)
  • Author(s): 細井勇人、池田裕明、日向千咲、王立楠、織戸由貴、今井奈緒子、糠谷育衛、榎竜嗣、峰野純一、竹迫一任、近藤哲、珠玖洋
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Multifunctionality determines T cellsurvival fate (2011)
  • Author(s): Imai N, Ikeda H, Tawara I, Hosoi H, MoriK, Hyuga C, Yamane M, Wang L, Shiku H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] In vivo persistence of adoptively transferred TCR gene-modified lymphocytes in patients with advanced esophageal cancer (2011)
  • Author(s): Kageyama S, Ikeda H, Miyahara Y, Hori S, Saito K, Imai N, Okamoto S, Tomura D, Nukaya I, Junichi Mineno J, Takesako K, Katayama N, Shiku H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Gene-modified T cell therapy : Harnessing lymphocytes for effective cancer treatment (2011)
  • Author(s): Ikeda H, Imai N, Hosoi H, Yamane M, Okamoto S, Mineno J, Takesako K, Kageyama S, Shiku H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] Antigen receptor gene-modified lymphocytes : harnessing T cells for effective cancer treatment (2011)
  • Author(s): Ikeda H, Imai N, Hosoi H, Yamane M, Okamoto S, Mineno J, Kageyama S, Takesako K, Shiku H
  • Organizer: 第17回日本遺伝子治療学会2011年次学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2011-07-16
• [Presentation] 遺伝子改変T細胞輸注療法 (2011)
  • Author(s): 池田裕明、今井奈緒子、細井勇人、山根真妃子、岡本幸子、峰野純一、竹迫一任、影山慎一、珠玖洋
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Book] がん生物学イラストレイテッド (2011)
  • Author(s): 今井奈緒子、池田裕明、珠玖洋
  • Total Pages: 260-268
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.shikuken.jp