2011 Fiscal Year Final Research Report
RegulationB of colon cancer progression by CDM protein DOCK4
| Project/Area Number |
22791276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWADA Kenji 京都大学, 医学研究科, 助教 (90322651)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / 転移 / 浸潤 |
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| Research Abstract |
Clinical studies with growth factor receptor tyrosine kinases (RTKs) inhibitors in cancer have met with a lot of promise and underscore the importance of this pathway in tumor biology. We present evidence for a novel intracellular signaling pathway linking RTK to the CDM Rac exchange factor DOCK4 via adaptor protein Grb2. In NIH3T3 cells, DOCK4 is required for PDGF dependent cell migration and PDGF receptorβ(PDGFRβ) endocytosis. In HCT116cells, DOCK4 is required for EGF-dependent cell migration and EGFR endocytosis. In addition, DOCK4 expression is increased in proportion to invasion depth and metastasis. These data may indicate that DOCK4 is a potential regulator of tumor progressio
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[Journal Article] Transcriptional factor Prox1 plays an essential role on the antiproliferative action of Interferon-gin esophageal cancercells2011
Author(s)
Akagami M, Kawada K, Kubo H, Kawada M, Takahashi M, Kaganoi J, Kato S, Itam i A, Shimad aY, Watanabe G, Sakai Y
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Journal Title
Ann Surg Oncol
Volume: 18(13)
Pages: 3867-77
DOI
Peer Reviewed
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[Journal Article] Molecular mechanisms of liver metastasis2011
Author(s)
Kawada K, Hasegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyama G, Okoshi K, Yamada M, Kawamura J, Taketo MM, Sakai Y
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Journal Title
Int J Clin Oncol
Volume: 16(5)
Pages: 464-72
DOI
Peer Reviewed
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