2011 Fiscal Year Final Research Report
Analysis of the role of transcriptional factor Prox1 using genetically modified mice
| Project/Area Number |
22791277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
OKOSHI Kae 京都大学, 医学研究科, 特定病院助教 (90534355)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / 遺伝子 |
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| Research Abstract |
Eleven types of ES clones were produced by gene transfer and three chimeras were obtained. By 2 times mating with FLP mice, five male and five female prox1+/-mice were obtained and they were confirmed by genotyping. We succeeded to prepare prox1-/-mice by mating prox1+/-mice. We investigated the role of Prox1 in the drug-induced esophageal cancer model using NMBA(N-nitrosomethylbenzylamine) under lack of the expression of Prox1 by infection of the Adeno-Cre.
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