Inflammation inducing resistance for anti-cancer drug

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: KOBAYASHI Shogo 大阪大学, 医学系・研究科, 助教 (30452436)
• Project Period (FY): 2010 – 2011
• Keywords: 胆道癌 / 化学療法抵抗性 / 胆道炎症 / アポトーシス

Research Abstract

Biliary tract cancer is commonly suffered from inflammation, such as cholangitis, obstructive jaundice, and liver abscess. In this study we evaluated the relationship between this inflammation and chemoresistance. The prognosis of the patients with possibility of cholangitis was poor and the surgical treatment to reduce cholangitis would have benefit for survival. IL-6 and TGF-βamong inflammation cytokines cross-talked in cholangiocarcinoma cells, and induced chemo-resistance for multi-anti cancer drugs. Induced Gemicitabine resistant cholangiocarcinoma cells produced IL-6 and TGF-βand inhibition of smad4 attenuate these chemo-resistance. These indicated that inflammation stimulated IL-6 and TGF-βproduction as cross-talk, which is one of the mechanisms of chemo-resistance for biliary tract cancer.

Research Products

• [Journal Article] Treatment of borderline cases for curative resection of biliary tract cancer (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: J Surg Oncol Volume: 104巻 Pages: 499-503
  • Peer Reviewed
• [Journal Article] Hiroaki Nagano Comparison of 4-weekly vs. 3-weekly gemcitabine as adjuvant chemotherapy following curative resection for biliary tract cancer : A prospective randomized controlled trial (2011)
  • Author(s): Shogo Kobayashi, Atsushi Miyamoto, Junzo Shimizu, Masaki Kashiwazaki, Yutaka Takeda, Shigeyuki Ueshima, Yongkook Kim, Toru Kitagawa, Keizo Dono, Masaki Mori, Yuichiro Doki
  • Journal Title: Journal of Cancer Therapy Volume: 2巻 Pages: 703-709
  • Peer Reviewed
• [Presentation] 進行胆道癌の長期生存例の臨床病理学的特徴とその術前予測 (2012)
  • Author(s): 小林省吾、永野浩昭、和田浩志、川本弘一、丸橋繁、江口英利、種村匡弘、梅下浩司、土岐祐一郎、森正樹
  • Organizer: 日本外科学会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-14
• [Presentation] 胆道癌におけるIL-6/ TGF-クロストークと化学療法耐性への影響 (2012)
  • Author(s): 山田大作、小林省吾、和田浩志、川本弘一、丸橋繁、江口英利、梅下浩司*、永野浩昭、土岐祐一郎、森正樹
  • Organizer: 日本外科学会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-13
• [Presentation] A prospective randomized controlled trial comparing 4-weekly versus 3-weekly adjuvant chemotherapy with gemcitabine after curative resection of biliary tract cancer (2012)
  • Author(s): Shin Nakahira, Shogo Kobayashi, Atsushi Miyamoto, Junzo Shimizu, Masaki Kashiwazaki, Shigeyuki Ueshima, Yongkook Kim, Toru Kitagawa, Keizo Dono, Masaki Mori, Yuichiro Doki and Hiroaki Nagano
  • Organizer: ASCO-GI
  • Place of Presentation: USA, Friday
  • Year and Date: 2012-01-20
• [Presentation] ゲムシタビン時代における非治療切除の意義 (2011)
  • Author(s): 小林省吾、丸橋繁、和田浩志、江口英利、種村匡弘、梅下浩司*、土岐祐一郎、森正樹、永野浩昭
  • Organizer: 日本胆道学会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-16
• [Presentation] 胆道癌治癒切除例に対するゲムシタビン術後補助化学療法の投与法別無作為化比較試験結果 (2011)
  • Author(s): 清水潤三、小林省吾、堂野恵三、鳥正幸、金よう国、中平伸、武田裕、柏崎正樹、宮本敦史、永野浩昭、土岐祐一郎、森正樹
  • Organizer: 日本胆道学会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-16
• [Presentation] いわゆる' Borderline-Curative Resection'症例に対する胆道癌の治療法の検討 (2010)
  • Author(s): 小林省吾、永野浩昭、和田浩志、丸橋繁、江口英利、武田裕、種村匡弘、梅下浩司、土岐祐一郎、森正樹
  • Organizer: 日本肝胆膵外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-27