2011 Fiscal Year Final Research Report
Explication of the mechanism of chemoresistance using video mass scope
| Project/Area Number |
22791282
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TSUTANI Yasuhiro 広島大学, 原爆放射腺医科学研究所, 助教 (10534985)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 抗癌剤耐性株 |
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| Research Abstract |
We performed microarray analyses for chemoresistant cell lines such as gastric cancer and esophageal cancer. We found chemoresistance related genes for 5-FU, oxaliplatin, and CPT-11, respectively. Especially, in oxaliplatin reistant cell lines, we discovered common up regulated genes such as AGR2, MUC4, LGALS7, GJB6, and KDM5D, and down regulated genes such as FLRT2, SLC25A27, ANKRD20A1, FRG1, and SAMD4A.
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