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2011 Fiscal Year Final Research Report

Explication of the mechanism of chemoresistance using video mass scope

Research Project

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Project/Area Number 22791282
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

TSUTANI Yasuhiro  広島大学, 原爆放射腺医科学研究所, 助教 (10534985)

Project Period (FY) 2010 – 2011
Keywords抗癌剤耐性株
Research Abstract

We performed microarray analyses for chemoresistant cell lines such as gastric cancer and esophageal cancer. We found chemoresistance related genes for 5-FU, oxaliplatin, and CPT-11, respectively. Especially, in oxaliplatin reistant cell lines, we discovered common up regulated genes such as AGR2, MUC4, LGALS7, GJB6, and KDM5D, and down regulated genes such as FLRT2, SLC25A27, ANKRD20A1, FRG1, and SAMD4A.

  • Research Products

    (3 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Upregulation of notch2and six1 is associated with progression of early-stage lung adenocarcinoma and a moreaggressive phenotype at advanced stages2012

    • Author(s)
      Mimae T, Okada M, Hagiyama M, Miyata M, Tsutani Y, et al
    • Journal Title

      Clinical Cancer Research

      Volume: 15 Pages: 945-55

    • Peer Reviewed
  • [Presentation] メタボローム解析によるヒト胃癌細胞株の抗がん薬に対する細胞内分子応答および耐性因子の探索2012

    • Author(s)
      笹田伸介
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千千葉
    • Year and Date
      20120412-14
  • [Presentation] 質量分析法を用いたヒト胃癌細胞株における抗がん薬に対する細胞内分子応答の解析2011

    • Author(s)
      笹田伸介
    • Organizer
      第83回日本胃癌学会総会
    • Place of Presentation
      青森
    • Year and Date
      2011-03-04

URL: 

Published: 2013-07-31  

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