2012 Fiscal Year Final Research Report
Development of reliable prediction system of early intrahepaticrecurrence of hepatocellular carcinoma after surgery
| Project/Area Number |
22791284
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 癌 |
|---|
| Research Abstract |
We developed prediction system of the risk of intrahepatic recurrence (IHR) of hepatocellular carcinoma (HCC) after surgery. IHR-related genes were screened by DNA microarray and an amplified fragment length polymorphism-based High Coverage Expression Profiling analyses. Nine genes were identified as IHR-related genes. Those 9 IHR-related genes showed significant differences of prognosis. Our prediction system consists of the combination of mRNA levels showed high performance to prediction of IHR within 2 years after surgery.
|
