2011 Fiscal Year Final Research Report
development of a novel beta-cell replacement therapy using the adipose-tissue derived stem cell(ADSC)
| Project/Area Number |
22791288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MORI Hiroki 徳島大学, 病院, 助教 (70448330)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脂肪由来幹細胞 / 膵島移植 / 糖尿病 |
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| Research Abstract |
β-cell replacement therapy using regeneration medicines is expected as a cure for type 1 diabetes. This time, after the human adipose-tissue derived stem cell(hADSC) transplant model using streptozotocin-induced diabetes nude mice will be created, we investigated the differentiated and derived impact of hADSC to the functional islet like cell in vivo, the homing effect of hADSC on injured islet cell in vivo and the cell protective effects of hADSC on injured islet cell in vitro. hADSC transplanted to pancreas itself was differentiated to functional islet like cell, and improved the abnormal glucose tolerance. Moreover, although, in vitro, hADSC had an islet cell protection effect without the cell-cell contact, in vivo, the homing effect on the injured islet cell by the intravenous injection was poor.
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