Detection of circulating tumor cells of hepatocellular carcinoma usingcancer stem cell markers

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791292
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kumamoto University (2010, 2012); Kyushu University (2011)
• Principal Investigator: MASUDA Toshiro 熊本大学, 医学部附属病院, 非常勤診療医師 (50551256)
• Research Collaborator: MIMA Kousuke 熊本大学, 医学部附属病院, 非常勤医師 (00546559)
• Project Period (FY): 2010 – 2012
• Keywords: 肝細胞癌 / CD90 / EpCAM / CD44 / 血中癌細胞 / 癌幹細胞

Research Abstract

Evaluating in 17 healthy volunteers and 36 hepatocellular carcinoma patients, FACS withthe markers of CD44, CD90, and EpCAM revealed that the proportion of CD90+ / CD45- cellswere higher in the patients of hepatocellular carcinoma, especially in Stage III / IVcases. With in vitro studies, six hepatocellular carcinoma cell lines expressed any twoof cancer stem cell markers such as CD90, CD133, CD44, EpCAM, and CD13

Research Products

• [Journal Article] Nutritional supports and infectionsassociated with hepatic resection andliver transplantation in patients with chronic liver disease. (2013)
  • Author(s): Masuda T, Shirabe K, Yoshiya S, MotonoR, Morita K, Hashimoto N, Ikegami T,Yoshizumi T, Baba H, Maehara Y
  • Journal Title: J Parenter Enteral Nutr Volume: 37 Pages: 318-26
  • DOI: DOI:10.1177/0148607112456041.
  • Peer Reviewed
• [Journal Article] Assessment of safety in hepaticresection for hepatocellularcarcinoma while focusing on indirecthyperbilirubinemia. (2013)
  • Author(s): Masuda T, Beppu T, Nakagawa S, OkabeH, Chikamoto A, Mima K, Otao R, Hayashi H, Doi K, Ishiko T, Takamori H, Baba H
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20 Pages: 370-4
  • DOI: DOI:10.1007/s00534-012-0540-8
  • Peer Reviewed
• [Journal Article] High CD44s expression is associatedwith the EMT expression profile andintrahepatic dissemination ofhepatocellular carcinoma after localablation therapy. (2013)
  • Author(s): Mima K, Hayashi H,Imai K, Kuroki H,Shigaki N, Nakagawa S, Okabe H,Chikamoto A, Watanabe M, Beppu T, BabaH
  • Journal Title: J Hepatobiliary Pancreatic Surg Volume: 20 Pages: 429-34
  • DOI: DOI:10.1007/s00534-012-0580-0
  • Peer Reviewed
• [Journal Article] Standard prophylactic strategyagainst peritoneal disseminationmetastasis in gastric cancer. (2013)
  • Author(s): Ikeshima S, Kuramoto M, Shimada S,Yamamoto K, Masuda T, Miyata T,Yoshimatsu S, Urata M, Baba H
  • Journal Title: J Cancer Ther Volume: 4 Pages: 99-103
  • DOI: DOI:10.4236/jct.2013.41A014
  • Peer Reviewed
• [Journal Article] Mima K, Hayashi H, Kuroki H, NakagawaS, Okabe H, Chikamoto A, Watanabe M,Beppu T, Baba H (2013)
  • Author(s): Mima K, Hayashi H, Kuroki H, NakagawaS, Okabe H, Chikamoto A, Watanabe M,Beppu T, Baba H
  • Journal Title: Oncology Lett Volume: 5 Pages: 149-154
  • DOI: DOI:10.3892/ol.2012.954
  • Peer Reviewed
• [Journal Article] CYLD down-regulation might berelated to tumor development in HCCpatients. (2013)
  • Author(s): Kinoshita H, Okabe H, Beppu T,Chikamoto A, Hayashi H, Imai K, MimaK, Nakagawa S, Yokoyama N, Ishiko T,Shinriki S, Jono H, Ando Y, Baba H
  • Journal Title: Mol Clin Oncol 1 Pages: 309-314
  • DOI: DOI:10.3892/mco.2013.68
  • Peer Reviewed
• [Journal Article] Hepatic resection combined withradiofrequency ablation for initiallyunresectable colorectal livermetastases after effectivechemotherapy is a safe procedure witha low incidence of local recurrence. (2012)
  • Author(s): Mima K, Beppu T, Chikamoto A, MiyamotoY, Nakagawa S, Kuroki H, Okabe H
  • Journal Title: Int J Clin Oncol
  • Peer Reviewed
• [Journal Article] CD44s regulates the TGF-β-mediatedmesenchymal phenotype and isassociated with poor prognosis inpatients with hepatocellularcarcinoma. (2012)
  • Author(s): Mima K, Okabe H, Ishimoto T, HayashiH, Nakagawwa S, Kuroki H, Watanabe M
  • Journal Title: Cancer Res Volume: 72 Pages: 3414-23
  • DOI: DOI:10.1158/0008-5472.CAN-12-0299.
  • Peer Reviewed
• [Journal Article] The expression levels of CD44v6 arecorrelated with the invasiveness ofhepatocellular carcinoma in vitro,but do not appear to be clinicallysignificant. (2012)
  • Author(s): Mima K, Okabe H, Ishimoto T, HayashiH, Nakagawa S, Kuroki H, Miyake K,Takamori H
  • Journal Title: Oncol Lett Volume: 5 Pages: 1047-1051
  • DOI: DOI:10.3892/ol.2012.611
  • Peer Reviewed
• [Journal Article] Combined measurements of serum bileacid level and splenic volume may beuseful to noninvasively assess theportal venous pressure. (2012)
  • Author(s): Hayashi H, Beppu T, Kuroki H, NakagawaS, Mima K, Okabe H, Nitta H, Imai K,Chikamoto A, Baba H
  • Journal Title: J Gastroenterol Volume: 47 Pages: 1336-1341
  • DOI: DOI:10.1007/s00535-012-0599-7.
  • Peer Reviewed
• [Journal Article] Kinoshita H, Okabe H, Beppu T,Chikamoto A, Hayashi H, Imai K, MimaK, Nakagawa S, Ishimoto T, Miyake K,Yokoyama N, Ishiko T, Baba (2012)
  • Author(s): Kinoshita H, Okabe H, Beppu T,Chikamoto A, Hayashi H, Imai K, MimaK, Nakagawa S, Ishimoto T, Miyake K,Yokoyama N, Ishiko T, Baba
  • Journal Title: Oncol Rep Volume: 29 Pages: 685-9
  • DOI: DOI:10.3892/or.2012.2162.
  • Peer Reviewed
• [Journal Article] Identification of CXCL5/ENA-78 as afactor involved in the interactionbetween cholangiocarcinoma cells andcancer-associated fibroblasts. (2012)
  • Author(s): Okabe H, Beppu T, Ueda M, Hayashi H,Ishiko T, Masuda T, Otao R, Horlad H,Mima K, Miyake K, Iwatsuki M, Baba Y,Takamori H, Jono H, Shinriki S, AndoY, Baba H
  • Journal Title: Int J Cancer 131 Pages: 2234-41
  • DOI: DOI:10.1002/ijc.27496
  • Peer Reviewed
• [Journal Article] External biliary drainage and liverregeneration after majorhepatectomy (2012)
  • Author(s): Otao R, Beppu T, Ishiko T, Mima K,Okabe H, Hayashi H, Masuda T,Chikamoto A, Takamori H, Baba H
  • Journal Title: Br J Surg Volume: 99 Pages: 1569-74
  • DOI: DOI:99DOI:10.1002/bjs.890
  • Peer Reviewed
• [Journal Article] Hepatic resection using a liverhanging maneuver and glissoneanpedicle transection forhepatocellular carcinoma in a patientwith situs inversus totalis (2012)
  • Author(s): Harada K, Masuda T, Beppu T, Ishiko T,Chikamoto A, Hayashi H, Okabe H, OtaoR, Tanaka H, Takamori H, Baba H
  • Journal Title: Report of a case. Surg Today Volume: 42 Pages: 801-804
  • DOI: DOI:10.1007/s00595-012-0156-2
  • Peer Reviewed
• [Journal Article] Liver hanging maneuver decreaseblood loss and operative time in aright-side hepatectomy. (2012)
  • Author(s): Beppu T, Ishiko T, Chikamoto A, KomoriH, Masuda T, Hayashi H, Okabe H, OtaoR, Sugiyama S, Nasu J, Horino K,Takamori H, Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 542-5
  • DOI: DOI:10.5754/hge09737.
  • Peer Reviewed
• [Journal Article] Amount of operative blood lossaffects the long-term outcome afterliver resection for hepatocellularcarcinoma. (2012)
  • Author(s): Chikamoto A, Beppu T, Masuda T, OtaoR, Okabe H, Hayashi H, Sugiyama S,Watanabe M, Ishiko T, Takamori H, Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 1213-6
  • DOI: DOI:10.5754/hge09778.
  • Peer Reviewed
• [Journal Article] Evaluation of the mass formingintrahepatic cholangiocarcinoma withviral hepatitis. (2012)
  • Author(s): Horino K, Beppu T, Kpmpri H, Masuda T,Hayashi H, Okabe H,Takamori H, Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 1217-9
  • DOI: DOI: 10.5754/hge09739
  • Peer Reviewed
• [Journal Article] Hybrid ablation using percutaneousand endoscopic approach formulti-nodular hepatocellularcarcinomas. (2012)
  • Author(s): Masuda T, Beppu T, Muzumoto T, Ishiko T, Chikamoto A, Hayashi H, Okabe H,Otao R, Hasita H, Takamori H, Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 836-9
  • DOI: DOI:10.5754/hge09738.
  • Peer Reviewed
• [Journal Article] Portal vein embolization canprevent intrahepatic metastases tonon-embolized liver. (2012)
  • Author(s): Okabe K, Beppu T, Masuda T, Hayashi H,Okabe H, Komori H, Horino K, SugiyamaS, Ishiko T, Takamori H, Yamanaka T,Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 538-41
  • DOI: DOI:10.5754/hge09764
  • Peer Reviewed
• [Journal Article] Laparoscopic and thoracoscopicthermal ablation for hepatocellularcarcinoma (2012)
  • Author(s): DoiK,BeppuT,IshikoT,ChikamotoA,MasudaT,TanakaH,KuramotoM,BabaH
  • Journal Title: J Microwave Surg Volume: 30 Pages: 225-230
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=ai1jmwse/2012/003000/033&name=0225-0230j&UserID=133.95.84.9
  • Peer Reviewed
• [Journal Article] Fetal-type glycogen phosphorylase(FGP) expression in intestinalmetaplasia as a high risk factor of thedevelopment of gastric carcinoma. (2012)
  • Author(s): Kuramoto M, Shimada S, Ikeshima S,Yamamoto K, Masuda T, Miyata T,Yoshimatsu S, Urata M, Baba H
  • Journal Title: Gastric Carcinoma- New Insights intoCurrent Management (edited by DanielaLazar, InTec (Vienna)) Pages: 93-110
  • DOI: DOI:10.5772/51793
  • Peer Reviewed
• [Journal Article] Hepatic stellate cells acceleratethe malignant behavior ofcholangiocarcinoma. (2011)
  • Author(s): DOI:10.5772/51793kabe H, Beppu T, Hayashi H, Ishiko T,Masuda T, Otao R, Shinriki S, HorladH, Jono H, Ueda M, Ando Y, Baba H
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 1175-84
  • DOI: DOI:10.1245/s10434-010-1391-7.
  • Peer Reviewed
• [Journal Article] Liver functional volumetry forportal vein embolization using anewly-developed 99mtc-galactosylhuman serum albumin scintigraphyspect-computed tomography fusionsystem. (2011)
  • Author(s): Beppu T, Hayashi H, Okabe H, Masuda T,Mima K, Sugiyama S, Horino K, Otao R,Chikamoto A, Doi K, Ishiko T, TakamoriH, Yoshida M, Shiraishi S, YamashitaY, Baba H
  • Journal Title: J Gastroenterol Volume: 46 Pages: 938- 43
  • DOI: DOI:10.1007/s00535-011-0406-x
  • Peer Reviewed
• [Journal Article] Safety and short-term therapeuticeffects of miriplatin-lipiodolsuspension in transarterialchemoembolization (TACE) forhepatocellular carcinoma. (2011)
  • Author(s): Okabe K, Beppu T, Haraoka K, Oh-UchidaY, Yamamura S, Tomiyasu S, Yamanaka T,Sano O, Masuda T
  • Journal Title: Anticancer Res Volume: 31 Pages: 2983-8
  • Peer Reviewed
• [Journal Article] Preoperative portal veinembolization (PVE) for patients withhepatocellular carcinoma can improveresectability and may improvedisease-free survival (2011)
  • Author(s): Okabe H, Beppu T, Ishiko T, Masuda T,Hasyashi H, Otao R, Hasta H, Okabe K,Sugiyama S, Baba H
  • Journal Title: J Surg Oncol Volume: 104 Pages: 641-6
  • DOI: DOI:10.1002/jso.21928.
  • Peer Reviewed
• [Journal Article] Laparoscopy-assisted resection ofan undiagnosed liver tumor andascending colon cancer via mini medianlaparotomy: report of a case. (2011)
  • Author(s): Mima K, Beppu T, Chikamoto A, IshikoT, Horino K, Hayashi N, Watanabe M,Takamori H, Okabe K, Yamanaka T, Baba H
  • Journal Title: Surg Today Volume: 41 Pages: 1633-8
  • DOI: DOI:10.1007/s00595-010-4524-5.
  • Peer Reviewed
• [Journal Article] Primary neuroendocrine tumor in theliver treated by hepatectomy. (2011)
  • Author(s): Mima K, Beppu T, Murata A, Otao R,Miyake K, Okabe H, Masuda T, Okabe K,Sugiyama S, Chikamoto A, Ishiko T,Takamori H, Baba H
  • Journal Title: Surg Today Volume: 41 Pages: 1655-60
  • DOI: DOI:10.1007/s00595-011-4497-z
  • Peer Reviewed
• [Journal Article] Pigmented hepatocellular adenoma:report of a case. (2011)
  • Author(s): Masuda T, Beppu T, Ikeda K, Ishiko T,Chikamoto A, Hayashi H, Okabe H, OtaoR, Takamori H, Namimoto T, Iyama K,Baba
  • Journal Title: Surg Today Volume: 41 Pages: 881-3
  • DOI: DOI:10.1007/s00595-010-4344-7.
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation incombination with hepatic resectionfor colorectal liver metastases. (2011)
  • Author(s): Beppu T, Mima K, Masuda T, Okabe H,Chikamoto A, Hayashi N, Ishiko T,Takamori H, Baba H
  • Journal Title: J Microwave Surg Volume: 29 Pages: 133-136
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=ai1jmwse/2011/002900/020&name=0133-0136j&UserID=133.95.84.9
  • Peer Reviewed
• [Journal Article] The Role of thermal ablation forcolorectal liver metastases in the eraof effective chemotherapy. (2011)
  • Author(s): Mima K, Beppu T, Masuda T, Otao R,Okabe H, Chikamoto A, Hayashi N,Ishiko T, Takamori H, Baba H
  • Journal Title: Thermal Med Volume: 27 Pages: 1-8
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=cn4thrma/2011/002701/001&name=0001-0036j&UserID=133.95.84.91
  • Peer Reviewed
• [Journal Article] The role of hepatic stellate cellsin the pathogenesis of hepatocellularand cholangiocarcinoma. (2011)
  • Author(s): Okabe H, Beppu T, Hayashi H, Ishiko T,Masuda T, Otao R, Horlad H, Baba H
  • Journal Title: Eur J Clin Med OncolEur J Clin Med Oncol Volume: 3 Pages: 64-68
  • URL: http://www.ejcmo.tv/wp-content/uploads/2012/12/The-Role-of-Hepatic-Stellate-Cells-in-the-Pathogenesis-ofHepatocellular-and-Cholangiocarcinoma.pdf
  • Peer Reviewed
• [Journal Article] A large splenic volume may be auseful predictor for partial splenicembolization-induced liverfunctional improvement in cirrhoticpatients.
  • Author(s): Hayashi H, Beppu T, Masuda T, Okabe H,Imai K, Hashimoto D, Ikuta Y,Chikamoto A, Watanabe M, Baba H
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Tumor compression-induced portalobstruction and selectivetransarterial chemoembolizationincrease functional liver volume inthe unobstructed area, facilitatingsuccessful resection of a large HCC:a case report.
  • Author(s): Tokunaga R, Hayashi H, Masuda T, MimaK, Chikamoto A, Tanaka H
  • Journal Title: Int Surg Volume: (in press)
  • Peer Reviewed
• [Presentation] CD44s regulates the TGF-β-mediatedmesenchymal phenotype and isassociated with poor prognosisin patients with hepatocellularcarcinoma. (2012)
  • Author(s): Mima K, Okabe H, Ishimoto T, HayashiH, Nakagawa S, Kuroki H, Watanabe M,Beppu T, Saya H, Baba
  • Organizer: The 8th International symposium oncancer research and therapy
  • Place of Presentation: 東京会館 東京都
  • Year and Date: 2012-11-10
• [Presentation] 長期予後からみた大腸癌肝転移に対する新規化学・分子標的治療併用肝切除の評価 (2012)
  • Author(s): 別府 透、今井克憲、坂本快郎、美馬浩介、岡部弘尚、新田英利、林 洋光、生田義明、 宮本裕士、 橋本大輔、 近本 亮、土居浩一、渡邊雅之、石河隆敏、馬場秀夫
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜 神奈川県
  • Year and Date: 2012-10-27
• [Presentation] アシアロ SPECT/Ctfusion を用いた右肝切除後肝再生の検討-門脈塞栓術の有無に着目して (2012)
  • Author(s): 新田英利、別府 透、林 洋光、今井克憲、中川茂樹、黒木秀幸、美馬浩介、橋本大輔、 生田義明、 近本 亮、 石河隆敏、吉田守克山下康行、馬場秀夫
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜 神奈川県
  • Year and Date: 2012-10-26
• [Presentation] 造影超音波を用いた経皮的および内視鏡的アプローチによるハイブリッド凝固療法 (2012)
  • Author(s): 新田英利、別府 透、中川茂樹、黒木秀幸、美馬浩介、今井克憲、林 洋光、中原 修、 生田義明、 近本 亮、 土居浩一、石河隆敏
  • Organizer: JDDW 2012
  • Place of Presentation: 神戸国際展示場 兵庫県
  • Year and Date: 2012-10-12
• [Presentation] 内頚静脈を用いた生体肝移植右葉グラフとの中肝静脈分枝再建の有用性についての検討 (2012)
  • Author(s): 宮田辰徳、 調 憲、 池上 徹、 吉屋匠平、武藤 純、間野洋平、戸島剛男、橋本真隆、森田和豊、萱島寛人、増田稔郎、吉住朋晴、馬場秀夫
  • Organizer: 第37回日本外科系連合学会学術集会
  • Place of Presentation: 九州大学医学部百年講堂・同窓会館 福岡県
  • Year and Date: 2012-06-29
• [Presentation] 肝細胞癌における癌幹細胞マーカーCD44 の上皮間葉形質転換(EMT)への関与 (2012)
  • Author(s): 美馬浩介、岡部弘尚、石本崇胤、中川茂樹、黒木秀幸、今井克憲、新田英利、生田義明、 近本 亮、 土居浩一、 高森啓史、別府 透、馬場秀夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ国際会議場 千葉県
  • Year and Date: 2012-04-13
• [Presentation] 肝細胞癌治療における門脈塞栓術の多角的効果 (2012)
  • Author(s): 別府 透、近本 亮、土居浩一、今井克憲、新田英利、岡部和利、増田稔郎、岡部弘尚、石河隆敏、高森啓史、馬場秀夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ国際会議場 千葉県
  • Year and Date: 2012-04-13
• [Presentation] 肝内胆管癌において EZH2 は癌の進展に関与する (2012)
  • Author(s): 中川茂樹、岡部弘尚、別府 透、黒木秀幸、美馬浩介、新田英利、今井克憲、生田義明、中原 修、近本 亮、土居 浩一、 石河隆敏、 高森啓史、 馬場秀夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ国際会議場 千葉県
  • Year and Date: 2012-04-13
• [Presentation] 肝内胆管癌の癌間質相互作用における CXCL5 の役割 (2012)
  • Author(s): 岡部弘尚、別府 透、植田光晴、石河隆敏、近本 亮、美馬浩介、中川茂樹、今井克憲、城野博史、高森啓史、安東由喜雄、馬場秀夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ国際会議場 千葉県
  • Year and Date: 2012-04-12
• [Presentation] CD44 standard isoform regulates themesenchymal phenotype inhepatocellular carcinoma cells, andassociates with a poor prognosis inpatients. (2012)
  • Author(s): Mima K, Okabe H, Ishimoto T, Beppu T,Baba H
  • Organizer: AACR Annual Meeting 2012
  • Place of Presentation: McCormick Place West Chicago(USA
  • Year and Date: 2012-04-03
• [Presentation] Identification of CXCL5/ENA-78regulating the interaction ofcholangiocarcinoma andcancer-associated fibroblasts. (2012)
  • Author(s): Okabe H, Beppu T, Ueda M, Hayashi H,Masuda T, Mima K, Nakagawa S, MiyakeK, Yokoyama N, Baba Y, Takamori H,Ishiko T, Jono H, Shinriki S,Ando Y,Baba H
  • Organizer: AACR Annual Meeting 2012
  • Place of Presentation: McCormick Place West Chicago(USA)
  • Year and Date: 2012-04-01
• [Presentation] Multiple utilities of portal veinembolization for patients withhepatocellular carcinoma. (2012)
  • Author(s): Beppu T, Okabe H, Okabe K, Masuda T,Mima K, Imai K, Hayashi H, Doi K,Chikamoto A, Ishiko T, Takamori H,Baba H
  • Organizer: ASCO 2012 Gastrointestinal CancersSymposium
  • Place of Presentation: The Moscone WestBuilding San Francisco(USA)
  • Year and Date: 2012-01-20
• [Presentation] 切除不能大腸癌肝転移の ConversionTherapy におけるラジオ波凝固療法の有用性 (2011)
  • Author(s): 美馬浩介、別府 透、馬場秀夫
  • Organizer: JDDW2011
  • Place of Presentation: 福岡サンパレス 福岡県
  • Year and Date: 2011-10-22
• [Presentation] Preoperative portal veinembolization can improve disease-freesurvival for patients withhepatocellular carcinoma. (2011)
  • Author(s): Beppu T,Chikamoto A, Baba H, Masuda T,Okabe H, Mima K, Ishiko T, Takamori H
  • Organizer: the 8th International Symposium onMinimal Residual Cancer
  • Place of Presentation: Osaka International Convention Center
  • Year and Date: 2011-09-21
• [Presentation] Preoperative portal veinembolization can improve disease-freesurvival for patients withhepatocellular carcinoma. (2011)
  • Author(s): Beppu T,Chikamoto A, Baba H, Masuda T,Okabe H, Mima K, Ishiko T, Takamori H
  • Organizer: INTERNATIONAL SURGICAL WEEK 2011
  • Place of Presentation: PACIFICO YOKOHAMA
  • Year and Date: 2011-08-28
• [Presentation] Preoperative tumor marker doublingtime is a prognostic factorfor hepatic resection ofhepatocellular carcinoma. (2011)
  • Author(s): PACIFICO YOKOHAMA
  • Organizer: INTERNATIONAL SURGICAL WEEK 2011
  • Place of Presentation: PACIFICO YOKOHAMA
  • Year and Date: 2011-08-28
• [Presentation] シアロ SPECT CT-fusion による分肝機能評価ー門脈塞栓術と肝切除例における有用性ー (2011)
  • Author(s): 増田稔郎、別府 透、近本 亮、美馬浩介、岡部弘尚、石河隆敏、馬場秀夫、吉田守克、白石偵哉、山下康行
  • Organizer: 第66回消化器外科学会総会
  • Place of Presentation: 名古屋国際会議場 愛知県
  • Year and Date: 2011-07-15
• [Presentation] 肝細胞癌における CD44isoform の上皮間葉形質転換(EMT) 、癌幹細胞性への関与の解明 (2011)
  • Author(s): 美馬浩介、 岡部弘尚、 別府 透、 近本 亮、増田稔郎、太田尾龍、堀野 敬、高森啓史、石河隆敏、馬場秀夫
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋国際会議場 愛知県
  • Year and Date: 2011-07-15
• [Presentation] 高ビリルビンを呈する肝細胞癌に対する肝切除の安全性と予後 (2011)
  • Author(s): 増田稔郎、 別府 透、 石河隆敏、 近本 亮、岡部弘尚、 美馬浩介、 阿部真也、 中原 修、田中 洋、堀野 敬、高森啓史、馬場秀夫
  • Organizer: 日本肝胆膵外科学会・学術集会
  • Place of Presentation: 京王プラザホテル 東京都
  • Year and Date: 2011-06-10
• [Presentation] 肝切除における合併症の予防のための機能的切除率評価と最新の肝切除手技 (2011)
  • Author(s): 増田稔郎、 別府 透、 石河隆敏、 近本 亮、岡部弘尚、太田尾 龍、美馬浩介、阿部真也、宮田辰徳、小澄敬祐、徳永竜馬
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 震災のため紙上発表
  • Year and Date: 2011-05-26
• [Presentation] Side population cells have somestem-like properties inhepatocellular carcinoma. (2011)
  • Author(s): Okabe H, Beppu T,Ishiko T,ChikamotoA,Masuda T,Otao R,Hasita H,MimaK,Takamori H,Baba H
  • Organizer: AACR102nd Annual Meeting 2011
  • Place of Presentation: Orange County ConventionCenter Orlando
  • Year and Date: 2011-04-22