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2011 Fiscal Year Final Research Report

Roles of XB130, a novel adaptor protein, in cell cycle progression of gastric cancer cells via regulation of c-Myc

Research Project

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Project/Area Number 22791295
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SHIOZAKI Atsushi  京都府立医科大学, 医学研究科, 助教 (40568086)

Project Period (FY) 2010 – 2011
Keywordsアダプター蛋白 / 胃癌 / 食道癌 / 細胞周期
Research Abstract

Adaptor proteins can participate in the regulation of various cellular functions, depending on the functional role of their interacting partners. We have cloned a novel adaptor protein, XB130, which has been implicated as a substrate and regulator of tyrosine kinase-mediated signaling and in controlling cell proliferation and apoptosis in thyroid and lung cancer cells. However, its expression and role in gastrointestinal cancer have not been investigated. In the present study, we sought to determine the role of XB130 in gastric and esophageal cancer cells and examine its expression and effects on the prognosis of patients with upper gastrointestinal cancer. Using knockdown experiments with XB130 siRNA, we found that XB130 regulate cell cycle progression via c-Myc and p21 in gastric and esophageal cancer cells. Immunohistochemical analysis revealed that expression of XB130 in cancer tissue was observed in 71.2% of patients with esophageal cancer, and that XB130 expression in the nucleus was an independent prognostic factor. The present study leads to the discovery of XB130 as an important prognostic factor in upper gastrointestinal cancer, and has the potential to present as a novel mediator and/or biomarker.

  • Research Products

    (42 results)

All 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (25 results)

  • [Journal Article] XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma2012

    • Author(s)
      Shiozaki A, Liu M, Otsuji E, et al
    • Journal Title

      Ann Surg Oncol

    • Peer Reviewed
  • [Journal Article] Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells2012

    • Author(s)
      Shiozaki A, Takeshita H, Liu M, et al
    • Journal Title

      PLoS One

      Volume: 7 Pages: e38049

    • DOI

      DOI:10.1371/journal.pone.0038049

    • Peer Reviewed
  • [Journal Article] Video-assisted surgery for gastric carcinoma arising in a gastric tube reconstructed via a retrosternal route2012

    • Author(s)
      Shiozaki A, Fujiwara H, Otsuji E, et al
    • Journal Title

      Surgery Today

      Volume: 42 Pages: 209-213

    • DOI

      DOI:10.1007/s00595-011-0029-0

    • Peer Reviewed
  • [Journal Article] Posterior mediastinal lymph node dissection using the pneumomediastinum method for esophageal cancer2012

    • Author(s)
      Shiozaki A, Fujiwara H, Otsuji E, et al
    • Journal Title

      Esophagus

      Volume: 9 Pages: 58-64

    • DOI

      DOI:10.1007/s10388-011-0304-6

    • Peer Reviewed
  • [Journal Article] Risk factors for postoperative respiratory complications following esophageal cancer resection2012

    • Author(s)
      Shiozaki A, Fujiwara H, Otsuji E, et al
    • Journal Title

      Oncol Lett

      Volume: 3 Pages: 907-912

    • DOI

      DOI:10.3892/ol.2012.589

    • Peer Reviewed
  • [Journal Article] Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury2012

    • Author(s)
      Oyaizu T, Shiozaki A, Liu M, et al
    • Journal Title

      Intensive Care Med

      Volume: 38 Pages: 894-905

    • DOI

      DOI:10.1007/s00134-012-2498-z

    • Peer Reviewed
  • [Journal Article] PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells2012

    • Author(s)
      Umehara S, Shiozaki A, Otsuji E, et al
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 61-66

    • DOI

      DOI:10.3892/ijo.2012.1454

    • Peer Reviewed
  • [Journal Article] Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre-and post-operative plasma2012

    • Author(s)
      Konishi H, Shiozaki A, Otsuji E, et al
    • Journal Title

      Br J Cancer

      Volume: 106 Pages: 740-747

    • DOI

      DOI:10.1038/bjc.2011.588.

    • Peer Reviewed
  • [Journal Article] Nodal Counts on MDCT as a Surrogate Marker for Surgical Curability in Gastric Cancer2012

    • Author(s)
      Kawaguchi T, Shiozaki A, Otsuji E, et al
    • Journal Title

      Ann Surg Oncol

    • DOI

      DOI:10.1245/s10434-012-2283-9

    • Peer Reviewed
  • [Journal Article] XB130, a Novel Adaptor Protein, Promotes Thyroid Tumor Growth2011

    • Author(s)
      Shiozaki A, Lodyga M, Liu M, et al
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 391-401

    • DOI

      DOI:10.1016/j.ajpath.2010.11.024

    • Peer Reviewed
  • [Journal Article] Roles of XB130, a novel adaptor protein, in cancer2011

    • Author(s)
      Shiozaki A, Liu M
    • Journal Title

      Journal of Clinical Bioinformatics

      Volume: 1 Pages: 10

    • DOI

      DOI:10.1186/2043-9113-1-10

    • Peer Reviewed
  • [Journal Article] Intracellular chloride regulates the G(1)/S cell cycle progression in gastric cancer cells2011

    • Author(s)
      Shiozaki A, Otsuji E, Marunaka Y
    • Journal Title

      World J Gastrointest Oncol

      Volume: 15 Pages: 119-122

    • DOI

      DOI:10.4251/wjgo.v3.i8.119

    • Peer Reviewed
  • [Journal Article] Self-assembling peptide-based nanoparticles enhance cellular delivery of the hydrophobic anticancer drug ellipticine through caveolae-dependent endocytosis2011

    • Author(s)
      Bawa R, Shiozaki A, Liu M, et al
    • Journal Title

      Nanomedicine

    • DOI

      DOI:10.1016/j.nano.2011.08.007

    • Peer Reviewed
  • [Journal Article] Blockade of Chloride Ion Transport Enhances the Cytocidal Effect of Hypotonic Solution in Gastric Cancer Cells2011

    • Author(s)
      Iitaka D, Shiozaki A, Otsuji E, et al
    • Journal Title

      J Surg Res

    • DOI

      DOI:10.1016/j.jss.2011.10.039

    • Peer Reviewed
  • [Journal Article] Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma2011

    • Author(s)
      Kosuga T, Shiozaki A, Otsuji E, et al
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 577-86

    • DOI

      DOI:10.3892/or.2011.1307

    • Peer Reviewed
  • [Journal Article] Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer2011

    • Author(s)
      Morimura R, Shiozaki A, Otsuji E, et al
    • Journal Title

      Br J Cancer

      Volume: 105 Pages: 1733-1740

    • DOI

      DOI:10.1038/bjc.2011.

    • Peer Reviewed
  • [Journal Article] Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma2011

    • Author(s)
      Komatsu S, Shiozaki A, Otsuji E, et al
    • Journal Title

      Br J Cancer

      Volume: 105 Pages: 104-111

    • DOI

      DOI:10.1038/bjc.2011.198.

    • Peer Reviewed
  • [Presentation] 気縦隔法を用いた食道切除術におけるロングデバイスの有効性2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      大阪
    • Year and Date
      20111207-09
  • [Presentation] 気縦隔法による食道切除術54例の治療経験とその有効性の検討2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      大阪
    • Year and Date
      20111207-09
  • [Presentation] 食道癌における気縦隔法を用いた後縦隔・腹腔リンパ節連続郭清手技2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      大阪
    • Year and Date
      20111207-09
  • [Presentation] 食道癌手術における気縦隔法を用いた安全な左後縦隔操作2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本臨床外科学会
    • Place of Presentation
      東京
    • Year and Date
      20111117-19
  • [Presentation] 気縦隔法を用いた食道切除術におけるロングエンシールの有効性2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本臨床外科学会
    • Place of Presentation
      東京
    • Year and Date
      20111117-19
  • [Presentation] 食道扁平上皮癌におけるKi67発現の検討2011

    • Author(s)
      飯高大介、塩崎敦、大辻英吾ら
    • Organizer
      日本癌治療学会
    • Place of Presentation
      愛知
    • Year and Date
      20111027-29
  • [Presentation] 気縦隔法による食道切除術, 50例の治療経験と有効性の検討2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本癌治療学会
    • Place of Presentation
      愛知
    • Year and Date
      20111027-29
  • [Presentation] 食道扁平上皮癌のxCT発現について2011

    • Author(s)
      飯高大介、塩崎敦、大辻英吾ら
    • Organizer
      日本胸部外科学会
    • Place of Presentation
      愛知
    • Year and Date
      20111010-12
  • [Presentation] 気縦隔法による食道癌後縦隔リンパ節郭清手技2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本胸部外科学会
    • Place of Presentation
      愛知
    • Year and Date
      20111010-12
  • [Presentation] 甲状腺癌における新規アダプター蛋白XB130の機能解析2011

    • Author(s)
      塩崎敦、市川大輔、大辻英吾ら
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知
    • Year and Date
      20111003-05
  • [Presentation] 食道扁平上皮癌におけるXB130の発現と機能2011

    • Author(s)
      小菅敏幸、塩崎敦、大辻英吾ら
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知
    • Year and Date
      20111003-05
  • [Presentation] 胃癌細胞株においてのクロライド輸送を阻害すると低浸透圧溶液の殺細胞効果が増強する2011

    • Author(s)
      飯高大介、塩崎敦、大辻英吾ら
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知
    • Year and Date
      20111003-05
  • [Presentation] Pleural Lavage with Distilled Water during Surgery for Thoracic Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Kosuga T, Shiozaki A, Otsuji E, etal
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      20110828-0901
  • [Presentation] The clinicopathological significance of xCT expression in esophageal squamous cell carcinoma2011

    • Author(s)
      Iitaka D, Shiozaki A, Otsuji E, et al
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      20110828-0901
  • [Presentation] Pneumomediastinum method for resection of esophageal duplication cyst2011

    • Author(s)
      Shiozaki A, Fujiwara H, Otsuji E, et al
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      20110828-0901
  • [Presentation] Pneumomediastinum method for esophageal cancer2011

    • Author(s)
      Shiozaki A, Fujiwara H, Otsuji E, et al
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      20110828-0901
  • [Presentation] 食道癌における新規アダプター蛋白XB130の発現と機能解析2011

    • Author(s)
      小菅敏幸、塩崎敦、大辻英吾ら
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      愛知
    • Year and Date
      20110713-15
  • [Presentation] 食道扁平上皮癌におけるxCT発現とその意義2011

    • Author(s)
      飯高大介、塩崎敦、大辻英吾ら
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      愛知
    • Year and Date
      20110713-15
  • [Presentation] HALS+気縦隔法を用いた食道切除術~ 30例の治療経験~2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      愛知
    • Year and Date
      20110713-15
  • [Presentation] 食道癌手術における蒸留水を用いた胸腔内洗浄の有効性2011

    • Author(s)
      小菅敏幸、塩崎敦、大辻英吾ら
    • Organizer
      日本外科学会
    • Year and Date
      20110000
  • [Presentation] 新規アダプター蛋白XB130の食道扁平上皮癌における発現と細胞周期制御2011

    • Author(s)
      小菅敏幸、塩崎敦、大辻英吾ら
    • Organizer
      日本食道学会
    • Place of Presentation
      宮城
    • Year and Date
      2011-09-26
  • [Presentation] 蒸留水(低浸透圧刺激)の食道癌細胞株に対する殺細胞効果の検討2011

    • Author(s)
      小菅敏幸、塩崎敦、大辻英吾ら
    • Organizer
      日本食道学会
    • Place of Presentation
      宮城
    • Year and Date
      2011-09-26
  • [Presentation] EBUS-TBNA(超音波気管支鏡ガイド下針生検)による食道癌縦隔再発診断2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本食道学会
    • Place of Presentation
      宮城
    • Year and Date
      2011-09-26
  • [Presentation] 気縦隔法によるサルベージ食道切除術の一例2011

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本食道学会
    • Place of Presentation
      宮城
    • Year and Date
      2011-09-26
  • [Presentation] 気縦隔法を用いた食道切除術39例の治療経験と有効性の検討2010

    • Author(s)
      塩崎敦、藤原斉、大辻英吾ら
    • Organizer
      日本食道学会
    • Place of Presentation
      宮城
    • Year and Date
      2010-09-26

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Published: 2013-07-31  

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