2011 Fiscal Year Final Research Report
The prevention of MRSA prosthetic vascular graft infection by using a DNA vaccine
| Project/Area Number |
22791309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | MRSA / DNAワクチン / 人工血管感染 |
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| Research Abstract |
I constructed DNA vaccine for the MRSA, and made an MRSA serious infectious disease model(mediastinitis caused by MRSA) and MRSA prosthetic vascular graft infection model. I failed to construct DNA vaccine by the method of the David M. Therefore I changed the means to the method of Hu DL. The new experimental plan goes, but I do not reach the stable composition of DNA vaccine. On the other hand, the bacteriological maneuver improved and I completed an MRSA mediastinitis model. I have been making the biofilm formation prosthetic vascular graft. The prosthetic vascular graft model is established at our department. It is necessary to realize stable supply of the DNA vaccine.
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