Anti-tumor effects of autophagy induction in malignant pleural mesothelioma.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791321
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: ASAKURA Keisuke 慶應義塾大学, 医学部, 共同研究員 (90383786)
• Project Period (FY): 2010 – 2011
• Keywords: 悪性胸膜中皮腫 / スタチン / オートファジー

Research Abstract

Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. Recent reports have indicated the potential efficacy of statins against malignant pleural mesothelioma cells in vitro. Here we show that lovastatin reduces primary tumor and metastasis in a mouse model of human malignant pleural mesothelioma, and that induction of autophagic changes may at least in part be involved in this process.

Research Products

• [Journal Article] The cytostatic effects of lovastatin on ACC-MESO-1 cells (2011)
  • Author(s): Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, Mizushima T, Ohmura M, Kawamura M, Wakui M, Adachi T, Nakamura M, Suematsu M, Nomori H
  • Journal Title: J Surg Res Volume: 170(2) Pages: e197-209
• [Journal Article] Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells (2011)
  • Author(s): Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H
  • Journal Title: Biochem Biophys Res Commun Volume: 410(2) Pages: 328-32