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2011 Fiscal Year Final Research Report

Anti-tumor effects of autophagy induction in malignant pleural mesothelioma.

Research Project

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Project/Area Number 22791321
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKeio University

Principal Investigator

ASAKURA Keisuke  慶應義塾大学, 医学部, 共同研究員 (90383786)

Project Period (FY) 2010 – 2011
Keywords悪性胸膜中皮腫 / スタチン / オートファジー
Research Abstract

Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. Recent reports have indicated the potential efficacy of statins against malignant pleural mesothelioma cells in vitro. Here we show that lovastatin reduces primary tumor and metastasis in a mouse model of human malignant pleural mesothelioma, and that induction of autophagic changes may at least in part be involved in this process.

  • Research Products

    (2 results)

All 2011

All Journal Article (2 results)

  • [Journal Article] The cytostatic effects of lovastatin on ACC-MESO-1 cells2011

    • Author(s)
      Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, Mizushima T, Ohmura M, Kawamura M, Wakui M, Adachi T, Nakamura M, Suematsu M, Nomori H
    • Journal Title

      J Surg Res

      Volume: 170(2) Pages: e197-209

  • [Journal Article] Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells2011

    • Author(s)
      Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410(2) Pages: 328-32

URL: 

Published: 2013-07-31  

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