2011 Fiscal Year Final Research Report
A mechanism of the aquaporin 1 expression control in the lung adenocarcinoma.
| Project/Area Number |
22791325
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肺腺癌 / アクアポリン1 / ヒストン修飾 / 術後転移 |
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| Research Abstract |
About the expression mechanism of aquaporin(AQP) 1, we studied to the histone modification of the epigenetics mechanism. AQP1 was not associated with histone modification directly. However, a postoperative recurrence and a stage and cell differentiation of lung cancer were associated with dimethylated histone3 lysine4(H3K4dime) which was histone modification one. H3K4dime was associated with HIF-1, too. H3K4dime is associated with extension and the grade of the lung cancer, and is important as a prognostic factor of lung cancer.
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