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2011 Fiscal Year Final Research Report

Overcoming therapy resistance of glioma cells via modulation of mitochondrial energy metabolism

Research Project

  • PDF
Project/Area Number 22791331
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionYamagata University

Principal Investigator

TOMIYAMA Arata  山形大学, 医学部, 助教 (40385810)

Project Period (FY) 2010 – 2011
Keywordsグリオーマ / エネルギー代謝
Research Abstract

In this study, we identified a chemical agent capable of promoting mitochondrial respiration of glioma cells and also confirmed that the chemical agent overcomes temozolomide resistance of glioma cells in vitro. In vivo, the chemical agent synergized with temozolomide to inhibit tumor growth in the subcutaneous xenograft model. However, the synergistic anti-tumor effect of these drugs remains to be demonstrated in the intracranial xenograft model.

  • Research Products

    (8 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011

    • Author(s)
      Sato A, Sunayama J, Matsuda K, Seino S, Suzuki K, Watanabe E, Tachibana K, Tomiyama A, Kayama T, Kitanaka C
    • Journal Title

      Stem Cells

      Volume: 29 Pages: 1942-1951

    • Peer Reviewed
  • [Journal Article] FoxO 3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011

    • Author(s)
      Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
    • Journal Title

      Stem Cells

      Volume: 29 Pages: 1327-1337

    • Peer Reviewed
  • [Journal Article] Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells2010

    • Author(s)
      Sunayama J, Matsuda KI, Sato A, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 1930-1939

    • Peer Reviewed
  • [Journal Article] Dual blocking of mTor and PI3K elicits a pro-differentiation effect on glioblastoma stem like-cells2010

    • Author(s)
      Sunayama J, Sato A, Matsuda KI, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
    • Journal Title

      Neuro-Oncol

      Volume: 12 Pages: 1205-1219

    • Peer Reviewed
  • [Presentation] グリオーマ幹細胞におけるFoxO3aを介した分化と造腫瘍能の制御2011

    • Author(s)
      佐藤篤, 砂山潤, 松田憲一朗, 立花研, 渡部江梨子, 清野静香, 鈴木香, 成田善孝, 渋井壮一郎, 富山新太, 北中千史, 嘉山孝正
    • Organizer
      第29回日本脳腫瘍学会学術総会
    • Place of Presentation
      下呂(水明館)
    • Year and Date
      2011-11-27
  • [Presentation] MEK inhibition enhances temozolomide sensitivity of glioma stem-like cells via MGMT down-regulation2011

    • Author(s)
      Sato A, Matsuda KI, Sunayama J, Sakurada K, Tachibana K, Tomiyama A, Kitanaka C, Kayama T
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(古屋国際会議場)
    • Year and Date
      2011-10-03
  • [Presentation] グリオーマ幹細胞におけるMGMT発現とテモゾロミド感受性に関する検討2010

    • Author(s)
      佐藤篤, 松田憲一朗, 砂山潤, 清野静香, 鈴木香, 櫻田香, 立花研, 富山新太, 北中千史, 嘉山孝正
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      軽井沢(軽井沢プリンスホテル)
    • Year and Date
      2010-11-28
  • [Presentation] Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the regulation of stemness of glioblastoma stem cells2010

    • Author(s)
      Sunayama J, Matsuda KI, Sato A, Tachibana K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2010-09-24

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Published: 2013-07-31  

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