2011 Fiscal Year Final Research Report
Research for personalized treatment according to the epigenetic profile of glioblastoma and glioma stem cell
| Project/Area Number |
22791334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Kuniaki 東京大学, 医学部附属病院, 助教 (50446564)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 膠芽腫 / エピジェネティクス / メチル化 / 網羅的解析 / CpG island methylator phenotype (CIMP) / Isocitrate dehydrogenase (IDH) / 腫瘍幹細胞 |
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| Research Abstract |
We extracted DNA from the glioma samples including glioblastoma and performed a methylation analysis of DNA promoter region and genetic anlaysis such as mutation of IDH and 1p19q codeltion. Genome-wide DNA methylation analysis identified G-CIMP and its strong association with IDH mutation. We selected CIMP markers which were differentially methylated in CIMP positive gliomas. CIMP marker genes showed distinct patterns of specific histone modification, suggesting the possibility of personalized treatment for the new targets.
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