2011 Fiscal Year Final Research Report
Genetic alteration of pediatric astrocytic tumors associated with malignant transformation
Project/Area Number |
22791337
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
|
Research Institution | Kanazawa University |
Principal Investigator |
KITA Daisuke 金沢大学, 附属病院, 助教 (10377385)
|
Project Period (FY) |
2010 – 2011
|
Keywords | 小児脳腫瘍 / 星細胞腫 / 遺伝子変異 / 悪性化機構 |
Research Abstract |
We assessed the relationship between histology and genetic alteration of pilocytic astrocytomas, and found there were strong correlation between BRAF gene alteration and histological accuracy. We then researched a tumor which had been diagnosed as pilocytic astrocytoma. We re-diagnosed it as anaplastic astrocytoma and found that the tumor could be associated with concomitant mutations of FAS and TP53, and it might progress secondarily from the long-standing diffuse astrocytoma via uncommon genetic alterations.
|
-
-
[Journal Article] The expression level ofsphingosine-1-phosphate receptor type 1 isrelated to MIB-1 labeling index andpredicts survival of glioblastoma patients2012
Author(s)
Yoshida, Y., Nakada, M., Harada, T., Tanaka, S., Furuta, T., Hayashi, Y., Kita, D., Uchiyama, N. and Hamada, J.
-
Journal Title
J Neurooncol
Volume: 98
Pages: 41-7
DOI
Peer Reviewed
-
[Journal Article] Secondary anaplastic astrocytomadeveloping in a young adult withautoimmune lymphoproliferativesyndrome(ALPS)2011
Author(s)
Kita, D., Hayashi, Y., Watanabe, T., Korshunov, A., von Deimling, A., Nakada, M., Kasahara, Y., Zen, Y. and Hamada, J
-
Journal Title
Neuropathol ApplNeurobiol
Volume: 37
Pages: 423-7
DOI
Peer Reviewed
-
[Journal Article] Thecorrelation between promoter methylationstatus and the expression level ofO6-methylguanine-DNA2011
Author(s)
Suzuki, T., Nakada, M., Yoshida, Y., Nambu, E., Furuyama, N., Kita, D., Hayashi, Y. and Hamada, J.
-
Journal Title
Jpn J Clin Oncol
Volume: 41
Pages: 190-6
DOI
Peer Reviewed
-
[Journal Article] Aberrant SignalingPathways in Glioma2011
Author(s)
Nakada, M., Kita, D., Watanabe, T., Hayashi, Y., Teng, L., Pyko, I. V. andHamada, J.
-
Journal Title
Cancers
Volume: 3
Pages: 3242-78
DOI
Peer Reviewed
-
[Journal Article] Recurrent anaplastic meningioma treatedby sunitinib based on results fromquantitative proteomics2011
Author(s)
Yoshikawa, A., Nakada, M., Ohtsuki, S., Hayashi, Y., Obuchi, W., Sato, Y., Ikeda, C., Watanabe, T., Kawahara, Y., Hasegawa, T., Sabit, H., Kita, D., Nakanuma, Y., Terasaki, T. and Hamada, J.
-
Journal Title
NeuropatholAppl Neurobiol
Volume: 38
Pages: 105-10
DOI
Peer Reviewed
-
[Journal Article] Sphingosine-1-phosphate receptor type 1regulates glioma cell proliferation andcorrelates with patient survival2010
Author(s)
Yoshida, Y., Nakada, M., Sugimoto, N., Harada, T., Hayashi, Y., Kita, D., Uchiyama, N., Yachie, A., Takuwa, Y. and Hamada, J.
-
Journal Title
Int JCancer
Volume: 126(10)
Pages: 2341-52
DOI
Peer Reviewed
-
[Journal Article] Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme : a report of 7 cases2010
Author(s)
Hayashi, Y., Nakada, M., Tanaka, S., Uchiyama, N., Kita, D. and Hamada, J
-
Journal Title
J Neurosurg
Volume: 112(5)
Pages: 1015-19
DOI
Peer Reviewed
-
[Journal Article] RNAi in Malignant BrainTumors2010
Author(s)
Nakada, M., Kita, D., Hayashi, Y., Kawasaki, K., Hamada, J. and Minamoto, T
-
Journal Title
Relevance to Molecular and Translational Research RNA Technologies and Their Applications
Pages: 107-129
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-