Regeneration of lesioned tract fibers in the adult brain

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Shinshu University
• Principal Investigator: FUKUSHIMA Nanae 信州大学, 医学部, 准教授 (90334888)
• Project Period (FY): 2010 – 2012
• Keywords: 神経再生 / 嗅覚機能 / 脳内伝導路

Research Abstract

Chondroitin sulfate proteoglycans (CSPGs) and myelin-associated proteins are known as axon-inhibitory molecules. Axonal regeneration after transection of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, was promoted in the adult brain by degradation of CSPGs or re-transection of the naturally regenerated-LOT that consisted of unmyelinated fibers.

Research Products

• [Journal Article] Moriizumi T. Analysis of spontaneous regeneration of olfactory structures with emphasis on myelination and re-innervation of cortical areas (2013)
  • Author(s): Fukushima N, Yokouchi K, Sakamoto M, Sekiguchi Y, Koike H, Kawagishi K
  • Journal Title: Neurosci Lett Volume: 537 Pages: 35-39
  • DOI: DOI:10.1016/j.neulet.2013.01.016
  • Peer Reviewed
• [Presentation] 成熟ラットにおける脳内伝導路の再生誘導 (2013)
  • Author(s): 福島菜奈恵, 横内久美子, 小池央, 川岸久太郎, 森泉哲次
  • Organizer: 第118回日本解剖学会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-29
• [Presentation] 新生児期外側嗅索損傷ラットにおける伝導路の再構築 (2012)
  • Author(s): 福島菜奈恵, 小池央, 横内久美子, 川岸久太郎, 掛川晃, 住友深憲, 森泉哲次.
  • Organizer: 第117回日本解剖学会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-28
• [Presentation] 外側嗅索再生の阻害因子に対するコンドロイチナーゼ ABC の効果 (2012)
  • Author(s): 小池央, 横内久美子, 川岸久太郎, 掛川晃, 住友深憲, 森泉哲次, 福島菜奈恵.
  • Organizer: 第117回日本解剖学会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-28
• [Presentation] 外側嗅索損傷新生児ラットにおいて出現する髄鞘化線維束について (2011)
  • Author(s): 福島菜奈恵, 横内久美子, 平山周一, 川岸久太郎, 森泉哲次
  • Organizer: 第45回日本味と匂学会
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-06
• [Presentation] Regeneration of the lateral olfactory tract in the neonatally tract-transected young adult rats (2011)
  • Author(s): 福島菜奈恵, 小池央, 横内久美子, 関口泰之, 川岸久太郎, 掛川晃, 住友深憲 , 森泉哲次
  • Organizer: 第116回日本解剖学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-30
• [Presentation] Induction of axonal regeneration by chondroitinase ABC in the lateral olfactory tract of adult rats (2011)
  • Author(s): 小池央, 福島菜奈恵, 横内久美子, 関口泰之, 川岸久太郎, 掛川晃, 住友深憲 , 森泉哲次
  • Organizer: 第1 1 6回日本解剖学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-30
• [Presentation] 外側嗅索再生へのイブプロフェンの効果 (2010)
  • Author(s): 関口泰之, 横内久美子, 福島菜奈恵, 川岸久太郎, 森泉哲次
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03