2011 Fiscal Year Final Research Report

Ctarification of pathophysiology of remodeling after intracranial artery inJury model in mice in dystipidemia

Research Project

Project/Area Number	22791341
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Osaka University
Principal Investigator	MUNEHISA Shimamura 大阪大学, 連合小児発達学研究科, 寄附講座准教授 (60422317)
Project Period (FY)	2010 – 2011
Keywords	脳血管内外科学 / リモデリング / 脳血管形成術 / 脂質異常症 / マウス
Research Abstract	In the present study, we established the intracranial artery injury model in mice. The temporal profile of remodeling was as follows : neointimal formation was grown from 28 days after injury ; re-endothelialization was started from day 7 ; inflammatory cells were observed from day 7 in the adventitia. These processes of remodeling were quite different from those in extracranial arteries. Using this model, we examined whether dyslipidemia had influences on the process of remodeling. To demonstrate it, Lp(a) transgenic mice, which showed high serum Lp(a) level, were exposed to the injury model. Unexpectedly, the extent of neointimal formation and the rate of re-endothelialization were not different between the groups. From the viewpoints, Lp(a) level might have no influences on remodeling after the injury in intracranial arteries.

(2 results)