2012 Fiscal Year Final Research Report
Intraarterial mesenchymal stem cell transplantation for traumatic brain injury
| Project/Area Number |
22791345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | びまん性軸索損傷 / 骨髄由来幹細胞 / 幹細胞移植 / 頭部外傷 / 神経再生 |
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| Research Abstract |
Using a fluid percussion device, we made severe traumatic brain injury model of rats. These rats were administrated mesenchymal stem cells via internal carotid artery. After then, we analyzed therapeutic effect behaviorally and immunohistochemically. Best therapeutic effect was obtained when we administrate MSC with mannitol by inducing blood brain barrier disruption. We are preparing for a manuscript for this study.
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