The role of TGF-βand approaches of new pharmacological treatments on cerebral aneurysm formation

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791347
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokushima
• Principal Investigator: KANEMATSU Yasuhisa 徳島大学, 病院, 助教 (90363142)
• Project Period (FY): 2010 – 2011
• Keywords: 脳動脈瘤 / TGF-β

Research Abstract

Transforming growth factor-beta(TGF-b) is a kind of cytokines. It is associated with the growth and rupture of aortic artery aneurysms(AAA). TGF-b is thought to be as a promising therapeutic target against AAA, however its role on cerebral aneurysms remains obscure. Using our aneurismal model, we observed the up-regulation of TGF-b in the aneurismal wall and the enhancement of it by pharmacological treatment, suggesting that TGF-b may is a promising therapeutic target on cerebral aneurysms

Research Products

• [Journal Article] A mouse model of intracranial aneurysm : technical considerations (2011)
  • Author(s): Tada Y, Kanematsu Y, Kanematsu M, Nuki Y, Liang EI, Wada K, Makino H, Hashimoto T.
  • Journal Title: Acta Neurochir Suppl Volume: 111 Pages: 31-5
  • DOI: DOI:10.1007/978-3-7091-0693-8_6
  • Peer Reviewed
• [Journal Article] Critical roles of macrophages in the formation of intracranial aneurysm (2011)
  • Author(s): Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T.
  • Journal Title: Stroke Volume: 42 Pages: 173-8
  • DOI: DOI:10.1161/STROKEAHA.110.590976
  • Peer Reviewed
• [Journal Article] Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats (2011)
  • Author(s): Tada Y, Kitazato KT, Yagi K, Shimada K, Matsushita N, Kinouchi T, Kanematsu Y, Satomi J, Kageji T, Nagahiro S.
  • Journal Title: Stroke Volume: 42 Pages: 2286-93
  • DOI: DOI:10.1161/STROKEAHA.110.608034
  • Peer Reviewed
• [Journal Article] Pharmacologically induced thoracic and abdominal aortic aneurysms in mice (2010)
  • Author(s): Kanematsu Y, Kanematsu M, Kurihara C, Tsou TL, Nuki Y, Liang EI, Makino H, Hashimoto T.
  • Journal Title: Hypertension Volume: 55 Pages: 1267-74
  • DOI: DOI:10.116/HYPERTENSIONAHA.109.140558
• [Presentation] ACTIVATION OF NUCLEAR RECEPTORS ON NEUROPROTECTION AFTER EXPERIMENTAL CEREBRAL ISCHEMIA IN FEMALE RATS (2012)
  • Author(s): Kohrai M, Kitazato KT., Kinouchi T, Shimada K, Sumiyoshi M, Matsushita N, Kanematsu Y, Satomi J, Kageji T, Nagahiro S.
  • Organizer: 80^<th> AANS
  • Place of Presentation: Miami, Florida
  • Year and Date: 20120414-18
• [Presentation] Excessive salt-intake exacerbates ischemic brain damage independent of blood pressure (2012)
  • Author(s): Sumiyoshi M, Kinouchi T, Tsutsumi T, Kitazato K, Shimada K, Matsushita N, Kanematsu Y, Satomi J, Nagahiro S.
  • Organizer: 80^<th> AANS
  • Place of Presentation: Miami, Florida
  • Year and Date: 20120414-18
• [Presentation] Influence of sodium retention on the formation of cerebral aneurysm (2012)
  • Author(s): Matsushita N, Kitazato K, Shimada K, Kinouchi T, Kanematsu Y, Satomi J, Nagahiro S
  • Organizer: 80^<th> AANS
  • Place of Presentation: Miami, Florida
  • Year and Date: 20120414-18
• [Presentation] High salt-intake under hypoestrogenicity exacerbates ischemic brain damage without affecting the blood pressure (2011)
  • Author(s): Sumiyoshi M, Kitazato KT, Kinouchi T, Tsutsumi T, Shimada K, Matsushita N, Kanematsu Y., Satomi J., Nagahiro S.
  • Organizer: Brain & Pet
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20110525-18