2011 Fiscal Year Final Research Report
The treatment of mouse brain tumor model with dendritic cells and adoptive immunotherapy
| Project/Area Number |
22791352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脳腫瘍 / 免疫治療 / 樹状細胞 / 養子免疫療法 / インターフェロン |
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| Research Abstract |
To make a contribution to clinical field, we examined the efficacy of immunotherapy for mouse brain tumor model with adoptive transfer and intratumoral delivery of dendritic cells in this study. First, mice with brain tumor received intratumoral injection of dendritic cells, and then received tumor antigen specific CD8 T cells intravenously. As a result, this combination of the treatment enhanced the homing of adoptive transferred T cells to the brain tumor site, and prolonged the survival time of the treated mice. The reason of this effective treatment was that intratumoral delivered dendritic cells made antigen presentation and induced chemokine production from tumor cells.
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