2013 Fiscal Year Final Research Report
Analysis of anti-nociceptive mechanism induced by gamma knife irradiation for intractable pain
| Project/Area Number |
22791358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
YAGASAKI Yuki 東京女子医科大学, 医学部, 助教 (90392422)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 機能脳神経外科学 / ガンマナイフ / 難治性疼痛 / 下垂体 / マクロファージ / 慢性炎症性疼痛 / 慢性神経因性疼痛 |
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| Research Abstract |
Gamma knife pituitary radiosurgery (GKPR) is used to manage cancer pain and has provided marked effects. However, the analgesic mechanism of GKPR remains unclear. We established a GKPR method for rats. Since pituitary atrophy was observed after high-dose GKPR, we confirmed that the GK irradiation had been correctly performed on the rat pituitary. Next, we determined the effects of 120Gy GK irradiation, a dose similar in energy to actual treatment, on the pituitary. However, no behavioral changes related to nociceptive responses were observed after GK irradiation of pituitary in the normal rat. Immunoblotting and histochemical analysis showed that Iba-1 positive cells (macrophage/microglia) were significantly increased at the GK treated pituitary. Further studies, such as GK irradiation of the pituitary in a chronic inflammatory pain model, may clarify the mechanisms underlying the anti-nociceptive effects induced by GK.
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