2011 Fiscal Year Final Research Report
Next generation sequencing of susceptibility loci for intracranial aneurysms to identify disease-causal mutations
| Project/Area Number |
22791359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
AKAGAWA Hiroyuki 東京女子医科大学, 医学部, テニュアトラック准教授 (60398807)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脳動脈瘤 / 遺伝子 / rare variant |
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| Research Abstract |
A susceptibility locus for intracranial aneurysms on chromosome14q23 was extensively analyzed with next generation sequencing. Positive linkage signal was successfully replicated in 14q22.3-14q24.3.
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[Journal Article] Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort2010
Author(s)
Krischek B, Tajima A, Akagawa H, Narita A, Ruigrok Y, Rinkel G, Wijmenga C, Feigl GC, Kim CJ, Hori T, Tatagiba M, Kasuya H, Inoue I
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Journal Title
Neuroscience
Volume: 169(1)
Pages: 339-43
Peer Reviewed
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