2011 Fiscal Year Final Research Report
A new treatment strategy for targeting the cancer stem cells in photodynamic therapy
| Project/Area Number |
22791362
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
INOUE Hiroto 大阪医科大学, 医学部, 非常勤医師 (00570532)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | がん幹細胞 / ABCG2 / ポルフィリン / 光線力学療法 / 5アミノレブリン酸 |
|---|
| Research Abstract |
As ABCG2 transporter, a main cause of chemo-resistance in cancer stem cells, also transports porphyrin to extracellular space, ABCG2 may be an effective target for photodynamic therapy. In this study, we proofed that gefitinib, a clinical available ABCG2 inhibitor, reduced extra-cellular transportation of porphyrin and increase intra-cellular concentration of porphyrin, consequently, enhanced the treatment efficacy of photodynamic therapy using 5-aminolevulinic acid.
|
