2011 Fiscal Year Final Research Report
ER Stress response in osteoclastogenesis
| Project/Area Number |
22791368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KOYAMA Kensuke 山梨大学, 医学部・附属病院, 助教 (80456491)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 破骨細胞 / 小胞体ストレス |
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| Research Abstract |
SubAB reduced arthritis score and synovitis in collagen induced arthritis(CIA) model mice. We used chronic model but the suppressive effects of SubAB was similar to acute model. We investigate osteoclasts in this model. TRAP positive osteoclasts in SubAB were less than control in pathological analysis. Next, we investigated the effects of SubAB to osteoclastogenesis in vitro. SubAB inhibited osteoclastogenesis directly in RAW264. 7 cell and mouse bone marrow cell. This concentration of SubAB did not affect differentiation of macrophage in mouse bone marrow cell.
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