2011 Fiscal Year Final Research Report
Development of novel biomaterial for intervertebral disc repair
| Project/Area Number |
22791374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
AKEDA Koji 三重大学, 医学部・附属病院, 講師 (20422826)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脊椎 / 椎間板変性 / 生体材料 |
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| Research Abstract |
Aggrecan(large proteoglycan) is one of the main extracellular matrix molecules of intervertebral disc(IVD). Gellan sulfate is a polysaccharide-biomaterial, whose chemical structure is similar to glycosaminoglycan. The purpose of this study was(1) to examine the effect of gellan sulfate(GS) on the extracellular matrix metabolism of bovine intervertebral disc(IVD) cells in vitro and(2) to evaluate the effect of injectable-GS on the progression of IVD degeneration in the rabbit IVD degeneration model. GS(32% sulfation rate) significantly stimulated the cell proliferation and proteoglycan synthesis of bovine IVD cells. Intradiscal injection of injectable-GS significantly inhibited the progression of disc height narrowing in the rabbit IVD degeneration model. Histological analysis showed that the injectable-GS had a high tissue affinity and increased the activation of matrix metabolism of rabbit IVD tissue.
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011
Author(s)
Satonaka H., Kusuzaki K., Akeda K., Tsujii M., Iino T., Uemura T., Matsubara T., Nakamura T., Asanuma K., Matsumine A., Sudo A
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Journal Title
Anticancer Res
Volume: 31
Pages: 4163-4168
Peer Reviewed
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