2011 Fiscal Year Final Research Report
Therapeutic effect of administration of microRNA on arthritis mice
| Project/Area Number |
22791385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 関節リウマチ / microRNA / 関節炎 / 炎症 / 関節破壊 |
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| Research Abstract |
The objective of this study was to examine whether the over-expression of miR-146 inhibits osteoclastogenesis, and prevent joint destruction by administration of miR-146a in collagen induced arthritis(CIA) mice. After the onset of distinct arthritis in CIA mice, ds miR-146a or scrambled siRNA was administered twice by intravenous injection. Radiographic and histological examinations were evaluated at 4 weeks. Administration of miR-146a could prevent joint destruction in CIA mice through the suppression of osteoclastogenesis and inflammation.
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