2011 Fiscal Year Final Research Report
The investigation of the bone metabolism in hypothalamus arcuate nucleus
| Project/Area Number |
22791395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Research Abstract |
To investigate the bone metabolism of AgRP neurons in the hypothalamus arcuate nucleus, we focused PDK1 which was a important neurotransmitter in PI3K pathway. We generated AGRP neuron-specific PDK1 knockout(AGRPPdk1-/-) mice and analyzed the bone metabolism of AGRPPdk1-/-mice. These mice showed oeteopenia. This singaling by AgRP neuron might control the GHRH-GH-IGF1 axis in the skeleton.
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