2011 Fiscal Year Final Research Report
Molecular mechanism of bone metabolism regulated by ubiquitin C-terminal hydrolase-L3
| Project/Area Number |
22791403
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 骨 / 軟骨代謝 |
|---|
| Research Abstract |
Ubiquitin C-terminal hydrolase-L3 deletion mice have high bone mass phenotype. Alkaline phosphatase activity was reduced in the UCH-L3 overexpressed osteoblast. No effect on osteoclast markers was found in UCH-L3 overexpressed osteoclast.
|
