The genotoxicity of occupational exposure to sevoflurane in anesthesiologists

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yamagata University
• Principal Investigator: OTAKI Kei 山形大学, 医学部, 助教 (60572980)
• Project Period (FY): 2010 – 2011
• Keywords: セボフルラン / コメットアッセイ / 麻酔科医師

Research Abstract

The alkaline comet assay was performed for detecting genotoxicity. There were no differences in the DNA damage of the peripheral lymphocytes between anesthesiologists and nonexposed control group. We found that endotracheal tube cuff pressure monitoring was decreased DNA damage significantly. However, it wasn't detected that chronic occupational exposure to sevoflurane and inhalation anesthetics caused DNA damage.