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2011 Fiscal Year Final Research Report

The study of new therapeutic target for intractable pain associated with acute pancreatitis

Research Project

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Project/Area Number 22791421
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Toyama

Principal Investigator

OISHI Mioko  富山大学, 大学病院, 助教 (10536733)

Project Period (FY) 2010 – 2011
Keywords疼痛管理学
Research Abstract

First, we found that the mRNA levels of interleukin-1b and monocyte chemotactic protein(MCP)-1 were significantly increased in the pancreas of caerulein-treated mice. The sensitivity of abdominal organs was enhanced in caerulein-injected mice, suggesting that caerulein caused pancreatic hyperalgesia. Moreover, repeated treatment with caerulein resulted in cutaneous tactile allodynia of the upper abdominal region indicating that caerulein-treated mice exhibited referred pain. Under this condition, the mRNA level of cox-2 was significantly increased in the spinal cord. The mRNA levels of bradykinin B1 receptor(BKB1R) and bradykinin B2 receptor(BKB2R) were significantly increased in the dorsal root ganglion. Finally, we found that intrathecal injection of celecoxib(selective cox-2 inhibitor) attenuated the acute pancreatitis pain-like state in caerulein-treated mice. These findings suggest that the upregulation of cox-2 in the spinal code and BK receptors in the DRG may, at least in part, contribute to the development of the acute pancreatitis pain-like state in mice.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] 慢性疼痛モデルと比較したセルレイン誘発急性膵炎モデルでの疼痛発現機構の検討2011

    • Author(s)
      竹村佳記、大石美緒子
    • Organizer
      日本臨床麻酔学会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-11-04

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Published: 2013-07-31  

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